摘要
目的:通过应用电喷雾-离子阱质谱,研究了炮制前后的川乌药材成分,以揭示川乌炮制减毒的原理。方法:对3种乌头对照品进行了离子阱多级质谱分析,归纳其裂解规律。对炮制前后的川乌药材进行液-质联用分析,并对各色谱峰进行归属。结果:通过对比炮制前后的质谱总离子流图及紫外色谱图,提出了川乌炮制减毒的两方面原因。结论:同时指出了将液-质联用技术引入中药炮制品的质量控制是十分必要的。
Objective： To reveal the processing principleg of preparation of Radix Aconiti by electrospray ionization trap mass spectrometry. Methods： The three reference standars were made MSn analysis and elucidating the fragmentation pathways. The rapid analysis by HPLC-ESI-MS had been used for identification of contituents in Radix Aconiti. Results：The comparison of mass spectra and liquid chromatographic information revealed the differences of Radix Aconiti and its process product. Conclusion ： It is necessary to make quality control of process product of traditional Chinese herbal medicines by HPLC-ESI-MS.
出处
《药学实践杂志》
CAS
2009年第5期349-352,共4页
Journal of Pharmaceutical Practice
关键词
川乌
离子阱质谱
炮制品
Radix Aconiti
electrospray ionization trap mass spectrometry
process product
