摘要
目的:探讨了恶性葡萄胎患者化疗前后血清胰岛素样生长因子-Ⅱ(IGF-Ⅱ)、上皮细胞生长因子(EGF)和肿瘤特异性生长因子(TSGF)水平的变化及意义。方法:应用放射免疫分析和生化法对31例恶性葡萄胎患者进行了血清IGF-Ⅱ、EGF和TSGF的检测,并与35名正常健康人作比较。结果:恶性葡萄胎患者在化疗前IGF-Ⅱ、EGF和TSGF水平均非常显著地高于正常人组(P<0.01)。经化疗后6个月,与正常人组比较仍有显著性差异(P<0.05)。结论:恶性葡萄胎患者的发生、发展与血清IGF-Ⅱ、EGF和TSGF水平的变化密切相关。
Objective To study the clinical significance of changes of serum IGF-Ⅱ,EGF and TSGF levels before and after chemotherapy in patients with malignant hydatidiform mole.Methods Serun IGF-Ⅱ,EGF levels（with RIA） and TSGF levels（with biochemistry method） were measured both before and after chemotherapy in 31 patients with malignant hydatidiform mole as well as in 35 controls.Results Before chemotherapy,serum IGF-Ⅱ,EGF and TSGF levels were significantly higher in the patients than those in controls（P〈0.01）.After six months＇ chemotherapy,serun IGF-Ⅱ,EGF and TSGF levels,though dropped markedly,remained significantly higher than those in controls（P〈0.05）.Conclusion Development of malignant hydatidiform mole in patients was closely related to the serum IGF-Ⅱ,EGF and TSGF levels.
出处
《放射免疫学杂志》
CAS
2009年第5期459-461,共3页
Journal of Radioimmanology
关键词
恶性葡萄胎
胰岛素样生长因子-Ⅱ
上皮细胞生长因子
肿瘤特异性生长因子
malignant hydatidiform mole
insulin-like growth factor-Ⅱ（IGF-Ⅱ）
epithelial growth factor（EGF）
tumor specific growth factor（TSGF）
