1McNicholl J M, Bond K B,Ruhadze E R,et al.Enhancement of HIV type 1 vaccine immunogenicity by block copolymer adjuvants(Ⅰ): Induction of high titer,long lasting,cross reactive antibodies of broad isotype [J].A2IDS Res H2um Retrovirus2es,1998,14 (16):1 457-1 471.
10Herbert W J.Mineraloiladjuvantsand the immunization of laboratory animals[M].In:We2irD M. Handbook of Experimental Immunology. 3rd edition. Oxford:Blackwell Scientific Publications,2003:A3.1 A3. 15.
4[2]Chu R S,Askew D,Noss E H,et al.CpG oligodeoxynucleotides sown-regulate macrophage class 11 MHC antigen processing[J].J Immunol,1999,163(3):1188-1194.
5[3]Bauer M,Heeg K,Wagner H,et al.DNA activates human immune cells through a CpG sequence-dependent manner[J].Immunology,1999,97(4):699-705.
6[4]SesterD P,Beasley S J,Sweet M J,et al.Bacterial/CpG-DNA down-modulates colony stimula-ring factor-1 receptor surfac,e expression on murine bone marrow-derived macrophages with concomitant growth arre stand factorindependent survival[J].J Immunol,1999,163:6541-6546.
7[6]郑明球.家畜传染病学试验指导[M].北京:中国农业出版社,1999.
8[7]Klinman D,Bamhart K,Conover J,et al.CpG motifs as immune adjuvants[J].Vaccine,1999,17:19.
9[8]Gilkeson G S,Grudier JP,Karounos D G,et al.Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA[J].J Immuno1,1989,142(5):1482-1486.
10[9]Krieg A M,YiA K,Matson S,et al.CPG motifs in bacterial DNA trigger direct B-cell activation[J].Nature,1995,374:546-549.
9McCartney SVermi W, Gilfillan S, Cella M, etal. Distinct and complementary functions of MDA5 and TLR3 inpoly (I:C)-mediated activation of mouse NK cells[J].Exp Med, 2009, 206: 2967-2976.
10Kenney RT, Cross AS.Adjuvants for the future.In ~ New Generation Vaccines[J].New York:Informa Healthcare USA,Inc., 2010: 250-262.
