摘要
急性胰腺炎(acute pancreatitis,AP)的发病机制尚不明确,通过动物实验及临床研究发现,缺血再灌注损伤在其发病机制中具有重要作用.微循环障碍、自由基生成增多、细胞内钙超载,炎性介质、白细胞及血小板的作用、肠源性内毒素血症等因素综合作用导致胰腺缺血再灌注损伤,这可能是AP发病环节中的共同通路.本文就胰腺缺血再灌注损伤的发生机制作一综述.
Though the pathogenesis of acute pancreatitis is still not entirely clear,animal experiments and clinical studies suggest that ischemia-reperfusion injury plays an important role in the development of acute pancreatitis.The combined action of microcirculatory disturbance,increased free radical production,intracellular calcium overload,inflammatory mediators,leukocyte-platelet interaction,intestinal endotoxemia and other factors leads to pancreatic ischemia-reperfusion injury.Thus,ischemia-reperfusion injury is fundamental to the pathogenesis of acute pancreatitis.In this article,we will review the mechanisms behind the development of pancreatic ischemia-reperfusion injury in acute pancreatitis.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第23期2400-2404,共5页
World Chinese Journal of Digestology
关键词
急性胰腺炎
缺血再灌注
发病机制
Acute pancreatitis Ischemia-reperfusion Pathogenesis
