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缺血修饰白蛋白及临床应用研究现状 被引量：2

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摘要 缺血修饰白蛋白(ischemia-modified albumin,IMA)是近年广受关注的心肌缺血早期诊断指标。它的生成是由于缺血发作时人血清白蛋白氨基酸末端序列乙酰化或缺失所致,IMA是迄今为止唯一经美国FDA批准上市销售用为临床诊断的心肌缺血生化标志物。缺血修饰白蛋白敏感性极高,对心肌缺血的早期诊断及预后均有很高的临床价值。但近年的大量研究发现其诊断心肌缺血的特异性较低,使其在临床的应用受到局限。本文作者就缺血修饰白蛋白临床研究现状作一综述,为其进一步的临床应用助益。
作者 李涯 屠洪 邓海
机构地区 广州医学院研究生院 深圳市第二人民医院心内科
出处 《深圳中西医结合杂志》 2009年第5期317-320,共4页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金 深圳市科技局2007计划项目(200703201)
关键词 缺血修饰白蛋白 心肌缺血 生化标志物
分类号 R542.2 [医药卫生—心血管疾病]
  • 相关文献

参考文献21

  • 1Defilippi IC,Yoon S,Ro A,et al.Early detection of myocardial ischemia by a novel blood based biomarker:the kinetics of ischemia modified albumin [J]. JACC,2003,41 (SupplA):A340.
  • 2Sinha MK,Gaze DC,Tippins JR,et al.lschemia modified albumin is a sensitive marker of myocardial ischemia after precutaneous coronary intervention[J].Circulation, 2003,107(19):2403-2407.
  • 3Garrido IP, Roy K,Calvino R,et al.Comparison of ischemia-modified albumin levels in patients undergoing precutaneous coronary intervenetion for unstable angina pectoris with versus without coronary collaterals[J].Am J Cardiol, 2004,93(1):88-90.
  • 4沈晓丽,邢超,韩莉莉,林粼,林立芳,邓玉莲,浦晓东,胡锡衷.缺血修饰白蛋白对急性心肌缺血早期诊断价值的探讨[J].中华心血管病杂志,2007,35(9):814-817. 被引量：25
  • 5Nihat K,Yakup C,Emrullah B,et al.Use of ischemamodified albumin in diagnosis of coronary artery disease [J].Coron Artery Dis,2007,18(8):633-637.
  • 6Bhagavan NV, Lai EM,Rios PA,et al.Evaluation of human serum albumin cobalt binding assay for the assessment of myocardial infarction[J].Chin Chem,2003, 49(4):581-585.
  • 7Peacock F, Morris DL,Anwaruddin S,et al.Meta-analysis of ischemia-modified albumin to rule out acute coronary syndrome in the emergency department(j).Am Heart J,2006,152(2):253-263.
  • 8Lucianno CS,Alberto BM,Sinha MK,et al.Ischemia- modified albumin predicts short-term outcome and 1-year mortality in patients attending the emergency department for acute ischemic chest pain [J]. Heart Vessels,2008,23(3): 174-180.
  • 9Dusek J,St'asek J,Tichy M,et al.Prognostic significance of ischemia modified albumin after precutaneous coronary intervention[J].Clin Chim Acta,2006, 367(1-2):77-80.
  • 10Sharma R,Gaze DC,Pellerin D,et al.lschemia-modified albumin predicts mortality in ESRD(J).Am J Kidney Dis,2006,47(3):493-502.

二级参考文献13

  • 1Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report. J Emerg Med,2000,19(4) :311-315.
  • 2Bhagavan NV, Lai EM, Rios PA, et al. Evaluation of human serum albumin cobalt binding assay for the assessment of myocardial ischemia and myocardial infarction. Clin Chem,2003, 49(4) :581-585.
  • 3Roy D, Quiles J, Gaze DC,et al. Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin. Heart, 2006,92(1) : 113-114.
  • 4Peacock F, Morris DL, Anwaruddin S, et al. Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department. Am Heart J,2006,152(2) :253-262.
  • 5Abadie JM, Blassingame CL, Bankson DD. Albumin cobalt binding assay to rule out acute coronary syndrome. Arm Clin Lab Sci, 2005,35(1 ) :66-72.
  • 6Roy D, Quiles J, Aldama G, et al. Ischemia modified albumin for the assessment of patients presenting to the emergency department with acute chest pain but normal or non-diagnostic 12-lead electrocardiograms and negative cardiactroponinT. Int J Cardiol, 2004,97(2) :297-301.
  • 7Cho DK, Choi JO, Kim SH,et al. Ischemia-modified albumin is a highly sensitive serum marker of transient myocardial ischemia induced by coronary vasospasm. Coron Artery Dis,2007,18( 2 ) : 83-87.
  • 8Quiles J, Roy D, Gaze D, et al. Relation of ischemia-modified albumin (IMA) levels following elective angioplasty for stable angina pectoris to duration of balloon-induced myocardial ischemia. Am J Cardiol,2003,92(3) :322-324.
  • 9Sinha MK,Gaze DC ,Tippins JR,et al. Ischemia modified albumin is a sensitive marker of myocardial ischemia after percutaneous coronary intervention. Circulation ,2003,107 ( 19 ) :2403-2405.
  • 10Apple FS, Quist HE, Otto AP, et al. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. Clin Chem, 2002,48(7) : 1097-1100.

共引文献24

同被引文献27

  • 1Baror D,Curtis G,Rao N,et al.Characterization of the Co2+ and Ni2+ binding mino-acid residues of the N-terminus of human albumin:an insight into the mechanism of a new assay formyocardial ischemia[J].Eur J Biochem,2001,268(6):42-47.
  • 2Lippi G,Montagnana M,Guidi GC.Albumin cobalt binding and ischemia modified albumin generation:An endogenous response to ischemia[J].IntJ Cardiol,2006,108(3):410-411.
  • 3Christenson RH,Duh SH,Sanhai WR,et al.Characteristics of an albumin cobalt binding test for assessment of acute coronary syndrome patients:a multicenter study[J].Clin Chem,2001,47(3):464-470.
  • 4Bar-Or D,Rael LT,Bar-Or R,et al.The cobalt-albumin binding assay:insights into its mode of action[J].Chin Chim Acta,2008,387(1-2):120-127.
  • 5徐骏 徐士荣.缺血修饰白蛋白和肌红蛋白在急性冠脉综合征诊断.当代医学,2008,14(12):55-56.
  • 6Bar-Or D,Winkler JV,Vanbenthuysen K,et al.Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty:a preliminary comparison to creatine kinase-KB,myoglobin and troponin I[J].Am Heart J,2001,141(6):985-991.
  • 7Hjortshoj SP,Dethlefsen C,Kristensen SR,et al.Kinetics of ischaemia modified albumin during ongoing severe myocardial ischaemia[J].Clin Chim Acta,2009:114-120.
  • 8Quiles J,Roy D,Gaze D,et al.Relation of ischemia modified albumin(IMA) levels following elective angiop lasty for stable anginapectoris to duration of balloon-induced myocardial ischemia[J].Am J Cardiol,2003,92(3):322-324.
  • 9Pollack CV,Peacoek FW,et al.Ischemia-modified albumin(IMA)is useful in risk stratification of emergency department chest pain patients[J].Acad Emerg Med,2003,10(5):555-556.
  • 10Aparci M,Kardesoglu E,Ozmen N,et al.Prognostic significance of ischemia-modified albumin in patients with acute coronary syndrome[J].Coron Artery Dis,2007,18(5):367-373.

引证文献2

深圳中西医结合杂志
2009年 第5期

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