摘要
目的观察参麦注射液联合吉西他滨(GEM)对老年非小细胞肺癌(NSCLC)患者生活质量(QOL)的影响。方法将42例患者随机分为治疗组和对照组各21例。治疗组给予参麦注射液40ml(d1-d14),GEM 1 000mg/m^2(d1、d8);对照组给予GEM1 000mg/m^2(d1、d8);两组均21 d为1个周期,至少完成2个周期。观察两组近期疗效、治疗后肿瘤患者生存质量评分(KPS评分)变化情况和毒副反应发生率。结果治疗组和对照组近期有效率分别为31.58%、25.00%,组间疗效比较,差异无统计学意义(P>0.05)。两组治疗后KPS评分均明显提高(P<0.05);治疗组和对照组KPS评分改善有效率分别为73.68%、50.00%,组间比较,差异有统计学意义(P<0.05)。治疗组血液学毒性和非血液学毒性发生率均明显低于对照组(P<0.05)。结论参麦注射液联合吉西他滨化疗可改善老年NSCLC患者生活质量,降低毒副反应发生率,具有一定的临床推广价值。
Objective To investigate the efficacy of＂Shenmai Injection＂combined with Gemcitabine（GEM） on the improvement of quality of life（QOL） in elderly NSCLC patients.Methods Forty-two subjects were randomly divided into research group and control group,21 patients in each group.In research group,patients were treated with 40 ml of＂Shenmai Injection＂from days 1 to 14,plus GEM 1000 mg/m2 on day 1 and day 8,and the regimen was performed every 3 weeks;in control group,patients were only treated with GEM 1000 mg/m2 on day 1 and day 8,the regimen was performed every 3 weeks.After at least two-cycle treatments,QOL,efficacy and toxicity were assessed.Results The difference of efficacy between two groups was not significant（31.58%vs 25.00%,P〉0.05）;the QOL enhanced in both research group and control group（P〈0.05）;the difference of KPS after treatment in two groups were markedly higher than before treatment（P〈0.05）;however,the effective rate on QOL was better in research group than in control
group（73.68%vs 50.00%,P〈0.05）;toxicity was also markedly lower than control group（P〈0.05）.Conclusion＂Shenmai Injection＂combined with GEM can enhance QOL in elderly NSCLC patients.
出处
《上海中医药杂志》
2009年第9期24-26,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市浦东新区科技攻关资助项目(PKJ2008-Y37)
关键词
非小细胞肺癌
中西医结合疗法
参麦注射液
吉西他滨
生活质量
毒副反应
Non-small cell lung cancer
combined Chinese and western medicine
＂Shenmai Injection＂
Gemcitabine
quality of life
toxicity
