摘要
目的分析支原体引起泌尿生殖系统感染的现状及药敏特征,为临床正确诊断和合理使用抗菌药物提供科学依据。方法支原体培养采用珠海市银科有限公司提供支原体鉴定/药敏试剂盒进行检测。结果1749例患者中,850例支原体培养阳性,阳性率为48.6%;女性阳性率为54.8%,高于男性27.9%;支原体阳性率呈逐年上升趋势。支原体感染中,Uu、Mh、Uu+Mh的阳性率分别为38.8%、1.4%、8.5%。两年统计比较Mh及Uu+Mh阳性率明显高于前一年。支原体对12种抗菌药物的敏感较好的是强力霉素(DOX)、美满霉素(MIN)、交沙霉素(JOS),敏感率分别为81.1%、77.3%、81.1%;对环丙沙星(CPF)、氧氟沙星(OFL)、螺旋霉素(ASP)、左旋氧氟(LEV)有较强的耐药性,耐药率分别为76.0%、55.8%、72.1%、69.4%。Uu+Mh混合感染的耐药率明显高于单一Uu及Mh感染。且支原体对12种药物的敏感率呈逐年下降趋势,多药耐药率逐年上升。结论泌尿生殖系统感染主要由Uu引起,占38.8%,Uu+Mh混合感染日趋严峻,药物敏感率逐年下降,多药耐药率逐年上升,治疗支原体感染应根据药敏结果,合理使用抗菌药物。
Objective To explore the status of mycoplasma in urogenital tract infection and drug- susceptibility characteristics, and to provide a scientific basis for correct diagnosis and reasonable use of medicine in clinic. Methods The kit produced by Zhuhai Yinke Corporation was used to culture mycoplasma strains and conduct drug susceptibility test. Results Among 1,749 cases, 850 were infected with mycolasma, with the total positive rate of 48.6 %. The positive rate of female （54.8%） was higher than that of male （27.9%）. The positive rate of mycolasma increased year by year. The positive rates of Uu, Mh and Uu ＋ Mh were 38.8 %, 1.4 % and 8.5 %, respectively. Two - year statistical analysis showed the positive rates of Mh or Uu ＋ Mh infection were both higher than those of the last year. The more sensitive were doxycycline （8 i. 8 % ）, minocycline （77.3 % ）, josamycin （81.1% ）. Drug resistance rates of ciprofloxacin （76.0%）, ofloxacin （55.8%）, spiramycin （72.1% ）, and oxyfluoride L （69.4 % ） were higher than other nine antibiotics. The resistance rate of Uu ＋ Mh mixed infection was significantly higher than those of Uu or Mh single infection, and the sensitive rate of antibiotics was lower and the resistance rate was higher than the last year. Conclusions Infection in urogenital tract is mainly due to Uu, with the infection rate of 38.8 %. Uu ＋ Mh mixed infection is more and more serious, the sensitive rate of antibiotics decreases year by year but the multidrug resistance rate increases yearly. We should reasonably choose and use antibiotics according to drug susceptibility.
出处
《实用预防医学》
CAS
2009年第5期1604-1606,共3页
Practical Preventive Medicine
