摘要
为了探讨胃肠激素在急性胃粘膜损伤中的变化和作用，该文观察了大鼠乙醇对胃粘膜损伤模型中胃粘膜局部胃肠激素含量的变化及其与胃粘膜损伤程度的关系。结果表明：随着乙醇作用时间延长，胃粘膜内生长抑素（ＳＳ）和血管活性肠肽（ＶＩＰ）含量显著下降，Ｐ物质的含量明显增加，从而使攻击因子作用加强，防御因子作用减弱；在乙醇作用３０ｍｉｎ后粘膜局部的表皮生长因子（ＥＧＦ）显著增高，这可能与机体的适应性保护有关。
To study the role of change on gastrointestinal hormone in ethanol-induced acute gastric mucosal injury in rats. We observed change on contents of gastrointestinal hormone in injured gastric mucosa and whose relations with degrees of gastric mucosal injury.The results showed while the time prolonging of ethanol action, the somatostatis(SS) and Vasoactive Intestinal Peptide(VIP) contents of gastric mucosa significantly decreased and the substance P(SP) contents significantly increased. The epidermal growth factor (EGF) contents of gastric mucosa significantly increased after ethanol induced gastric mucosal injury for thirty minutes. This suggested that the changes of gastrointestinal hormone might participate in the pathophysiology mechanisms of ethanol-induced gastric mucosal injury.
出处
《中国现代医学杂志》
CAS
CSCD
1998年第11期9-10,共2页
China Journal of Modern Medicine
关键词
乙醇
胃粘膜损伤
胃肠激素
病理
Ethanol
Gastric mucosal injury
Gastrointestinal hormone
