4Haworth R, Pilling A M. The PCR assay in the preclinical safety evaluation of nucleic acid medicines[ J]. Hum Exp Toxicol. 2000,19:267-276.
5Ledwith B J, Manam S, Troilo P J, et al, Plasmid DNA vaccine: investigation of integration into host cellular DNA following intramuscular injection in mice[ J]. Intervirology. 2000,43 (4-6) :258-272.
6Manam S, Ledwith B J, Bmum A B, et al. Plasmid DNA vaccines: tissue distrbution and effects of DNA sequence, adjuvants anddelivery method on integration into host DNA [ J ]. Intervirology. 2000,43 (4-6) : 273-281.
7Kang K K, Choi S M, Choi J H, et al. Safety evaluation of GX212, a new HIV therapeutic vaccine: investigation of integration into the host genome and expression in the reproductive organs[ J]. Intervirology. 2003,46( 5 ) :270- 276.
8Ramsay A J, Kent S J, Strugnell R A,et al. Genetic vaccination strategies for enhanced cellular, humoral and mucosal immunity[ J]. Immunol Rev, 1999,171 ( 1 ) :27.
9Kawabata K, Takakura Y, and Hashida M. The fate of plasmid DNA after intravenous injection in mice:involvement of scavenger receptors in its hepatic uptake [ J ]. Pharm Res, 1995,12 (6) :825.
10Chun S, Daheshia M, Lee S, et al. Distribution fate and mechanism of immune modulation following mucosal delivery of plasmid DNA encoding IL-10 [ J ]. J Immunol, 1999,163 (5) :2393.
