摘要
目的:比较三餐前门冬胰岛素30注射液皮下注射(TID)与三餐前门冬胰岛素30注射液联合睡前甘精胰岛素皮下注射(MSⅡ)强化控制2型糖尿病(T2DM)的疗效差异。方法:64例T2DM患者随机分为2组,分别给予TID和MSⅡ进行短期强化达标治疗,比较治疗后7个时点血糖均值、血糖达标时间、达标时胰岛素用量、治疗第14天胰岛素用量、低血糖发生例/次。结果:治疗后7个时点血糖均值、低血糖发生例/次,2组间差异无统计学意义。TID组与MSⅡ组治疗后空腹血糖分别为(6.32±0.89)、(5.79±0.83)mmol.L-1,血糖达标时间分别为(8.59±2.73)、(6.44±2.83)d,达标时胰岛素用量分别为(31.50±11.16)、(41.44±12.10)IU.d-1,治疗第14天胰岛素用量分别为(24.91±10.83)、(33.63±13.01)IU.d-1,2组间差异均有统计学意义(P<0.05)。结论:2种胰岛素强化治疗均能促进T2DM患者血糖短期达标,且低血糖发生率差异无统计学意义。TID组显著减少胰岛素用量,但在降低空腹血糖、缩短血糖达标时间方面,MSⅡ优于TID。
OBJECTIVE： To evaluate the curative efficacy of biphasic insulin aspart 30 hypo prior three meals（TID） in combination with insuline glargine injection hypo at bedtime vs. multiple subcutaneous insulin injection （MSII） as intensification therapies in the treatment of type 2 diabetes mellitus （T2DM） .METHODS： 64 T2DM cases were randomized to either TID group or MSII group for intensive short term treatment. The MBG （mean blood glucose）, the time to meet BG target, the insulin dosage at the time when BG met the target, the insulin dosage at 14 days, and the occurring cases/ times of hypoglycemia etc of the two groups at 7 different time points were compared. RESULTS： There were no significant differences between the two groups in either MBG or the occurring cases/times of hypoglycemia at 7 different time points. The fasting blood glucose（FBG） was （6.32± 0.89） mmol·L^-1 for TID group vs. （5.79± 0.83） mmol ·L^-1 for MSII group; the average time to meet the target BG level was （8.59 ± 2.73） days for TID group vs. （6.44± 2.83） days for MSII group; the insulin dosage when BG met the target was （31.50± 11.16） IU·d^-1 vs. （41.44± 12.10） IU ·d^-1, and the insulin dosage at 14 days was （24.91 ± 10.83） IU ·d^-1 vs. （33.63± 13.01） IU·d^-1, all showing significant differences between the two groups （P〈 0.05） . CONCLUSION： Both intensification therapies could effectively promote the blood glucose in T2DM patients to meet target values within short term; moreover, there were no significant differences between the two therapies in the incidence of hypoglycemia. In TID group, the insulin dosage was significantly decreased, but MSII group is superior to TID group in decreasing FBG and shortening the time for BG to meet target level.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第29期2291-2293,共3页
China Pharmacy
