摘要
目的本研究利用人血白蛋白免疫损伤Ｗｉｓｔｅｒ大鼠造成肝纤维化模型，以观察“抑肝纤”对大鼠肝纤维化的阻断作用。方法将不同浓度中药“抑肝纤”用于治疗组并与模型组和对照组进行对比，综合分析血清肝纤维化指标、肝组织病理改变、肝组织胶原纤维和网状纤维病理图像定量分析等结果。结果治疗组血清肝纤维化指标（ＰＣⅢ、ＨＡ、ＬＮ）均低于模型组，接近正常组，差异有显著性（Ｐ＜０．００１或Ｐ＜０．０５）。光镜下肝组织病理变化，肝组织中胶原纤维和网状纤维病理图像定量分析结果治疗组优与模型组，尤以低浓度组更为明显（Ｐ＜０．００５或Ｐ＜０．０５）。结论研究结果表明，中药“抑肝纤”如能早期应用。
Aims:In order to observe the effects of troditional herbs Yi gan xian preventing hepatic fibrosis from experimental rats immuno damaged.Metheds:Treatment groups with various doses troditional herbs yi gan xian were compared with model group which were immuno damaged by human serum albumin and control group.Level of serum PCⅢ HA LN,change of hepatic tissue pathology and analysis of collagenous fibers and reticular fibers pathology picture in the liver were synthesized.Results:serum PCⅢ HA LN in the treatment group were lower than model group (P<0.001或P<0.05).Pathology change under microscope and results of analysing collagenous fibers and reticular fibers pathology picture in the liver were obviously better than model group especially in the lower dose group (P<0.005 or P<0.05).Conclussion:If troditional herbs Yi gan xian were early used,it can effectively prevents hepatic fibrosis from experimental rats.
出处
《中国中医基础医学杂志》
CAS
CSCD
1998年第9期19-22,共4页
JOURNAL OF BASIC CHINESE MEDICINE
关键词
免疫性肝损伤
肝纤维化
中医药疗法
Liver immuno damaged hepatic fibrosis analysis of hepatic pathology picture troditional herbs Treatment
