摘要
病理学和流行病学研究表明不利的母体内环境,如母体蛋白质摄入不足、高胆固醇血症、糖尿病(DM)、吸烟等,均可增加子代发生心血管疾病的风险。在子宫内,胎盘和胎儿直接接收来自母体的多种代谢信号:抗氧化剂及促炎、抗炎信息等,并产生特异性应答,致使胚胎DNA甲基化、染色体修饰等过程发生改变,对子代产生持久性的影响,继而导致胎儿成年后动脉粥样硬化(AS)的易感性增强。文中就母体不利因素对子代发生动脉粥样硬化危险性的影响及其相关信号传递和作用机制作一综述。
Epidemiological and pathological evidence has demonstrated that adverse in utero environment, such as protein restriction, hypercholesterolemia, diabetes and smoking, can increase the risk of vascular disease in the offspring. In utero, the placenta and fetus are exposed to the metabolic, antioxidant and pro-inflammatory and anti-inflammatory signals from the mother and likely to make specific responses, which may lead to permanent changes either in DNA methylation or chromatin modification or both, and these changes, in turn, may result in increased atherosclerosis susceptibility in adulthood. In this review, we briefly summarize the possible signals crossing the placental barrier and discuss the molecular mechanisms of epigenetic programming in the developing fetus that may lead to increased atherosusceptibility of the vessel wall.
出处
《医学研究生学报》
CAS
2009年第9期984-988,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金资助项目(批准号:30872411)
