摘要
目的：探讨继发性高促性腺激素性闭经妇女的骨代谢状况。方法：对１２例继发性高促性腺激素性闭经妇女，１２例同龄正常妇女及８例自然绝经妇女的空腹２小时尿钙与肌酐比值（Ｃａ／Ｃｒ）、尿羟脯氨酸与肌酐比值（ＯＨＰｒ／Ｃｒ）、血碱性磷酸酶（ＡＫＰ）、血骨钙素（ＢＧＰ）、血降钙素（ＣＴ）、血白细胞介素Ⅵ（ＩＬ－６）及血雌二醇（Ｅ２）水平进行测定与比较。结果：继发性高促性腺激素性闭经组与正常对照组相比，＜Ｅ２血ＣＴ水平显著降低（Ｐ＜００１），尿Ｃａ／Ｃｒ、尿ＯＨＰｒ／Ｃｒ比值及血ＡＫＰ、血ＢＧＰ、血ＩＬ－６水平均明显增高（Ｐ＜００１）。继发性高促性腺激素性闭经组与自然绝经组相比，尿Ｃａ／Ｃｒ比值及血ＢＧＰ水平明显低于自然绝经组（Ｐ＜００５），血Ｅ２水平，尿ＯＨＰｒ／Ｃｒ比值、血ＡＫＰ、血ＣＴ及血ＩＬ－６水平无明显统计学差异（Ｐ＞００５）。结论：继发性高促性腺激素性闭经妇女与同龄正常妇女相比，骨代谢呈高转换负钙平衡状态，此状态的出现与其ＣＴ分泌减少。
Objective: To study the bone metabolism in women with secondary hypergonadotropic amenorrhea. Methods: The study subjects comprised 32 women who were divided into 3 groups: secondary hypergonadotropic amenorrhea group(n=12), age-matched control group(n=12) and natural menopause group(n=8). Bone metabolic parameters were determined,which include 2-h fasting urinary calcium/creatinine(Ca/Cr) and hydroxyproline/creatinine (OHPr/Cr) ratios, serum alkaline phosphatase(AKP), Calcitonin(CT), bone glaprotein(BGP), interleukin-6(IL-6) and estradiol(E2). Results: Serum levels of E2 and CT were significantly lower, urinary Ca/Cr, OHPr/Cr ratios, serum levels of AKP, BGP, IL-6 were significantly higher in secondary hypergonadotropic amenorrhea group than those in control group. The Ca/Cr ratio and the level of BGP in the secondary hypergonadotropic amenorrhea group were significantly lower than those in natural menopause group. Conclusion: Compared with the normal age-matched women, bone metabolism in secondary hypergonadotropic amenorrhea group is negative calcium balance, which is a associated with the decrease of CT and the inerease of IL-6. \ \
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1998年第5期279-281,共3页
Chinese Journal of Practical Gynecology and Obstetrics
