摘要
【目的】通过研究消化不良患儿空腹血浆ghrelin水平变化及其与患儿消化不良症状的相关性,探讨gh-relin水平与消化不良症状发生的关系。【方法】测定25例器质性消化不良患儿、20例功能性消化不良患儿和15例健康体检儿童空腹血浆ghrelin水平,并对患儿消化不良症状进行评分。比较三组ghrelin水平差异,分析ghrelin水平与患儿消化不良症状的相关性。【结果】①器质性消化不良组和功能性消化不良组血浆ghrelin水平比较差异无显著性(P>0.05),但均显著高于正常对照组(P<0.05);②血浆ghrelin水平与患儿呕吐、餐后饱胀、早饱、纳减症状积分均呈显著负相关(P<0.05),与上腹疼痛、上腹不适、恶心均无显著相关(P>0.05)。【结论】血浆ghrelin水平下降与消化不良症状的发生及严重程度有一定相关性。
[Objective] To explore the relation between plasma ghrelin and dyspepsia by investigating variation of fasting ghrelin levels and its correlation with symptoms. [Methods] 25 children with organic dyspepsia（OD） ,20 children with functional dyspepsia（Fib） and 15 health controls were enrolled in the study. Fasting plasma ghrelin concentrations were measured. The score of dyspepsia symptoms was recorded in children with dyspepsia. Then plasma ghrelin levels were measured among the three groups and their relation to symptoms of dyspepsia were investigated. [Results] Ghrelin levels in OD Children and FD ones were not statistically significant different（P〉0.05）, but were significantly lower than in controls （P〈0. 05）. Fasting plasma ghrelin levels showed significant relation with scores of vomiting, postprandial fullness, early satiation, appetite loss （P〈0.05）, but not with scores of nausea,epigastric pain or epigastric discomfort （P〉0. 05）. [Conclusion] The decreased plasma ghrelin levels may have relation with the development and severity of dyspepsia symptoms.
出处
《中国儿童保健杂志》
CAS
2009年第5期581-583,共3页
Chinese Journal of Child Health Care
