摘要
目的发展适合我国慢性血吸虫病疾病负担评价的伤残权重,从而更准确地评估其疾病负担。方法以全球疾病负担研究中疾病的六级失能等级标准为依据,评定我国慢性血吸虫病的年龄别和性别平均伤残权重。通过问卷对湖北省阳新县血吸虫病监测点的219例慢性血吸虫病患者进行调查,全部数据采用EpiData3.1软件建库,应用SAS8.1软件进行分析。分别采用秩和检验、Kruskal-Wallis检验比较性别和年龄别伤残权重,用Nemenyi法对年龄别伤残权重进行两两比较,并通过多因素累积logistic回归模型分析伤残权重的影响因素。结果我国湖区慢性血吸虫病患者伤残权重均值为0.122。年龄别伤残权重为0.020～0.280,高于全球疾病负担研究中确定的0.005～0.006。伤残权重值随着年龄增长呈上升趋势,年龄组差异有统计学意义(χ2=152.590,P<0.01)。男、女性伤残权重分别为0.103和0.147,女性明显高于男性(Z=2.405,P<0.05)。多因素累积logistic回归分析显示,伤残权重具有明显的年龄依赖性(OR=1.173,95%可信区间为1.130～1.217),收入水平是重要的保护因子(OR=0.497,95%可信区间为0.319～0.775),而性别是一个混杂因子。结论慢性血吸虫病患者每存活一年平均损失近1/8个健康寿命年,该评定结果高于全球疾病负担研究的确定值。
Objective To estimate a suitable disability weight for chronic schistosomiasis japonica in a lake area of China. Methods A total of 219 chronic schistosomiasis patients from surveillance sites in Yangxin County of Hubei Province received questionnairing. The age- and sex-specific disability weights of chronic schistosomiasis were estimated based on the six classes of disability severity identified by Global Burden of Disease （GBD）. All data was managed by Epidata 3.1. Statistical analysis was performed using SAS8.1. Rank sum test and Kruskal-Wallis test were used to examine the differences between disability weights. Pair-wise comparison was done by Nemenyi method. Multi- factor logistic regression was used to analyze the risk factors of disability weight. Results The average disability weight was 0.122, and age-specific weight ranged from 0.020 to 0.280. The disability weight increased with age. Significant differences were found among different age groups （χ2=152.590, P〈0.01）. The disability weight of males （0.103） was significantly lower （Z=2.405, P〈0.05） than that of females （0.147）. Multi-factor logistic regression models indicated that the disability weight was significantly associated with age （OR=1.173, 95% CI： 1.130～1.217）, and income level was a protective factor （OR=0.497, 95% CI： 0.319～0.775）, while age was a confounding factor. Conclusion An average disability weight of 0.122 for chronic schistosomiasis japonica indicates that 1/8 healthy year has lost for each survived life year of the patients, higher than the data of GBD.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2009年第4期303-306,共4页
Chinese Journal of Parasitology and Parasitic Diseases
基金
湖北省卫生厅血防科研联合攻关项目(No.XF06C30)~~
关键词
慢性血吸虫病
伤残权重
疾病负担
Chronic schistosomiasis
Disability weight
Disease burden
