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Anti—NGF在躯体疾病疼痛治疗中的潜在价值 被引量：2

Potentials of anti-nerve growth factor therapy in pathological pain management
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摘要 神经生长因子（nervegrowthfactor．NGF）属神经营养因子家族，广泛分布于中枢及外周神经系统，不仅在神经系统的发育存活中起重要作用，而且参与外周伤害性疼痛感受的产生与调节。近年来由于对NGF在急、慢性疼痛及痛觉过敏中作用的认识不断增强．一种新的抑痛方法一一抗-NGF（anti-NGF）治疗悄然兴起。它是通过NGF的抗血清IgG封闭NGF,抑制其与受体结合及受体的自磷酸化作用，从而部分阻断或减弱疼痛的进程。由于该方法抑痛效果明显，且不与神经营养因子家族的其他成员作用，尚未发现明显不良反应及成瘾性，对中枢神经系统也无直接作用，因此极有可能成为疼痛治疗的新热点。
作者 李雁 张绍芬
机构地区 复旦大学附属妇产科医院妇科
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2009年第9期961-963,共3页 Chinese Journal of Neuromedicine
关键词 神经生长因子 抗神经生长因子治疗 病理性疼痛 Nerve growth factor Anti-nerve growth factor therapy Pathologic pain
分类号 R686 [医药卫生—骨科学]
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参考文献18

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同被引文献30

  • 1Levgur M,Abadi MA,Tucker A.Adenomyosis:symptoms,histology,andi pregnancy termination[J].Obstet Gynecol,2002,95:688-691.
  • 2Sammour A,Pirwany I,Usubutun A,et al.Correlation between extent and spread of adenomyosis and clinical symptoms[J].Gyuecol Obstet Invest,2002,54:213-216.
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  • 4Huang HY,Yu HT,Chan SH,Lee CL,Wang HS,Soong YK Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial myometrial interface in adenomyosis patients[J].Fertil Steril,2010,94:33-39.
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  • 6Zhang G,Dmitrieva N,Liu Y,et al.Endometriosis as a neurovascular condition:estrous variations in innervation,vascularization,and growth factor content of ectopic endometrial cysts in the rat[J].Am J Physiol Regul Integr Comp Physiol,2008,294:R162-171.
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  • 8Li Y,Zhang SF,Zou SE,et al.Accumulation of nerve growth factor and its receptors in the uterus and dorsal root ganglia in a mouse model of adenomyosis[J].Reprod Biol Endocrinol,2011,9:30.
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  • 10Berkley KJ.A life of pelvic pain[J].Physiol Behav,2005,86:272-280.

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二级引证文献57

中华神经医学杂志
2009年 第9期

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