摘要
目的：探讨消疤软膏皮肤用药的安全性。方法：用家免皮肤刺激性试验，分为完整皮肤组和破损皮肤组，连续给药7d后取给药皮肤进行病理检查；用豚鼠皮肤主动过敏性试验（ACA），于第0、7、14天右侧去毛皮肤致敏，第28天左侧去毛皮肤激发，观察消疤软膏是否引起豚鼠皮肤或全身过敏反应。结果：家兔皮肤刺激性试验完整皮肤组肉眼观察无红斑水肿，家兔破损皮肤在1～5d内出现的红斑和水肿现象是由于皮肤损伤引起的炎症反应所致，而不是用药所致，同时病理组织学检查未见明显异常；皮肤主动过敏试验未引起豚鼠皮肤过敏反应和全身过敏反应。结论：消疤软膏未引起动物皮肤的刺激性和过敏性反应。
Objective： To study the safety of Xiaoba Ointment in dermatological application. Methods： Skin irritation test： by using of rabbit as the test animal, divided into two groups, which were normal skin group and ruptured skin group. Applied continuously administration for 7 days, then stopped dosing for the next 7 days. Gave pathology test for the two groups on the 8th day. ACA test： sensitized the right side of the skin of cavy on 0,7th and 14th day, and then stimulated the left side of the skin on the 28th day, to observe whether or not the Xiaoba ointment would lead to skin or body allergic. Results： For skin irritation testing： there are no visible erythema or edema occurred in normal group rabbit. Contrarily, in the ruptured skin group, erythema and edema had occurred from 1st day to 5th day, but that was because of the damage but not administration. And no exceptional histopathology was found at the same time. So there were no skin or body allergic reaction to cavy. Conclusion： Xiaoba ointment had not led skin irritation or anaphylactoid for test animals.
出处
《亚太传统医药》
2009年第9期41-44,共4页
Asia-Pacific Traditional Medicine
关键词
消疤软膏
皮肤刺激性
皮肤过敏性
Xiaoba ointment
Skin irritation reaction
Skin anaphylactoid reaction
