摘要
目的探索新生儿肺出血的发病机制和早期监测的方法，为防治肺出血提供理论基础。方法对新生儿窒息和新生儿硬肿症的肺出血和无肺出血患儿血液中血栓素Ｂ２（ＴＸＢ２）和纤维蛋白肽Ａ（ＦＰＡ）进行了对照观察。分别采用高效液相色谱法及放射免疫法测定血浆ＦＰＡ和ＴＸＢ２的浓度。同时对肺出血患儿作血气分析。结果新生儿硬肿症肺出血组和新生儿窒息肺出血组ＴＸＢ２及ＦＰＡ的浓度无明显差异（Ｐ＞０．０５）；新生儿硬肿症肺出血组ＴＸＢ２及ＦＰＡ值较新生儿硬肿症无肺出血组、正常新生儿组明显升高（Ｐ＜０．０１）；新生儿窒息肺出血组ＴＸＢ２及ＦＰＡ值较新生儿窒息无肺出血、正常新生儿组明显升高（Ｐ＜０．０１）。结论新生儿肺出血患儿存在血小板活化和异常凝血；窒息和硬肿症所致的新生儿肺出血都存在止血凝血功能障碍这一共同因素；
Objective To study the pathophysiology and early diagnostic indices in neonates with pneumorrhagia. Methods The plasma fibrinopeptide A (FPA) and thromboxane B_2 (TXB2) were measured by high performance liquid chromatography and radioimmuroassay, respectively, in 18 neonates with pneumorrhagia. In addition the blood gas analysis was performed. Results There was no difference in TXB2 and FPA between neonates with pneumorrhagia caused by scleroderma and those caused by asphyxia (P>0.05). The levels of TXB2 and FPA, however, were much higher in neonates with pneumorrhagia caused by scleredema than those in neonatal scleredema and normal neonates (all P<0.01). The levels of TXB2 and FPA were also significantly higher in neonales with pneumorrhagia caused by neonatal asphyxia than in those with asphyxia and normal neonates (all P<0.01). Conclusions Coagulation dysfunction does exist in neonates with pneumorrhagia caused by scleredema and asphyxia. Plasma TXB2 and FPA should be considered as the early objective monitoring indices in neonates who are highly suspected as having pneumorrhagia.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1998年第8期479-481,共3页
Chinese Journal of Pediatrics
关键词
新生儿
血栓烷B2
纤维蛋白肽A
肺出血
Lung diseases Infant, newborn Thromboxane B_2 Fibrinopeptides A Hemorhage
