摘要
本文研究3,4-二取代-1,2,4-三唑-5-硫酮的 Mannich 反应,制得一系列1-胺甲基-3-(4-唑啶基/5-甲基异唑噁-4-芳基-芳基-1,2,4-三唑啉-5-硫酮[Ⅲ],进而证明[Ⅰ]进行 Mannich 反应时,胺甲基化只发生在化合物1-位氮原子上,而不是在硫原子上.
Orientation in Mannich reaction of a series of 3-( 4-pyridyl/5-methyl-isoxazol-3-yl)-4-aryl-1,2,4-triazolin-5-thione(Ⅰ)has beenstudied.The result reveals,that when compound(I)possessing one activehydrogen condensed with formaldehyde and a secondary amine such aspiperidine or morpholine in dioxane,a series of Mannich bases are obtainedin moderate yield,the aminomethylation preferably located at the N1 ofcompounds(Ⅰ)to thionation.
出处
《兰州大学学报（自然科学版）》
CAS
CSCD
北大核心
1990年第3期78-83,共6页
Journal of Lanzhou University(Natural Sciences)
关键词
酰氨基硫脲
杂环衍生物
1,2,4-triasolin-5-thione
mannich reaction piperidine
morpholine 6-Methyl-isoxazol
