摘要
目的证明无胸水肺癌患者胸膜腔内存在游离癌细胞并探讨术中蒸馏水热灌注化疗对生存期的影响。方法对320例无胸水肺癌患者术中进行了胸腔冲洗液细胞学检查。于开胸后探查前冲洗,收集冲洗液后立即细胞学检查,阳性者随机分为A组和B组,A组关胸前应用43℃顺伯(80mg)蒸馏水(1000mL)灌注化疗,B组未给予治疗常规关胸。结果阳性患者87例(27.2%)。A组与B组1、3、5生存率分别为95.5%、72.7%、56.8%;100%、41.9%、27.9%。结论无胸水肺癌患者胸膜腔内有游离癌细胞存在,术中蒸馏水热灌注化疗能提高阳性肺癌患者5年生存率。
Objective To demonstrate the existence of free carcinoma cells in the pleural cavity of patients with lung cancer accompanied without pleural effusion, to evaluate the effect of pleural perfusion hyperthermo-chemotherapy combined with operation on the impact of survival time. Methods The Pleural Lavage Cytology Examination was conducted in 320 patients with lung cancer and lung excision accompanied without pteural effusion.Pleural lavage fluid was rinsed after thoractemy but before examination,and was collected and used to carry out the cytology examination immediately. Positives were randomly divided into two groups： treatment （group A） and control group （group B）. Treatment group underwent intrapleural perfusion with 43 degrees saline solution（1000mL） containing cisplatin （80rag） for 60minutes.Results The cytological results of the pleural lavage fluid were positive for malignant cells in 87of 320 patients （27.2%）. 1,3,5-year survival rate of group A and group B were 95.5%, 72.7%, 56.8%, 100%,41.9%, 27.9% respectively. Conclusion Exfoliated free carcinoma cells may be present in the pleural cavity of patients with lung cancer accompanied without pleural effusion. Hyperthermo-chemotherapy combined with operation can improve the 5-year survival rate of the positive patients with lung cancer.
出处
《中外医疗》
2009年第27期4-5,共2页
China & Foreign Medical Treatment
关键词
支气管肺癌
细胞学检查
胸腔冲洗液
低渗温热化疗
Lung cancer
Cytological examination
Pleural lavage fliud
Hyperthermo-chemotherapy
