摘要
Toll样受体（Toll-like receptors，TLR）是表达在哺乳动物细胞表面的一类重要的模式识别受体，是进化中比较保守的一个受体家族，TLR能特异地识别病原体相关分子模式，不仅在激活天然免疫中发挥着重要的作用，而且还调节获得性免疫，是连接天然免疫与特异性免疫的主要桥梁。研究表明，TLR是介导宿主对结核杆菌的识别及抗结核免疫反应的关键分子，与抗结核感染免疫有关的主要是TI，R2和TLR4。对TLR的研究有助于阐明结核病的发病机制并为其治疗提供崭新的策略。
Toll-like receptors （TLR）, a family of pattern recognition receptors expressed on mammalian cell surface, are evolutionarily conserved to recognize pathogen-associated molecular patterns. The activation of TLR not only initiates innate immunity, but also regulates enhanced antigen-specific acquired immunity, and thus associates innate and adaptive immunity. Study showed that TLR are hostmediated recognition of Mycobacterium tuberculosis and anti-TB immune response key elements, and that the anti-tuberculosis infection immunity related is mainly TLR2 and TLR4. Research on TLR contributes to a clarification of the pathogenesis of TB and provides the brand-new strategy for its treatment.
出处
《国际呼吸杂志》
2009年第17期1054-1057,共4页
International Journal of Respiration
