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骨髓基质干细胞向有功能性神经细胞诱导分化的研究进展

Progress in the study on induction of bone marrow stromal cells into mature functional neural cells
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摘要 骨髓基质干细胞（BMSCs）是成体干细胞的一种，广泛存在于人体的间充质组织中，具有较强的自我复制能力和多向分化潜能；单独或联合使用某些诱导剂和细胞基因方面的干预，可使其在体外培养条件下向某一谱系细胞分化且不改变多向分化和增殖能力；同时具有独特的免疫学特征，是理想的组织工程种子细胞。近几年发现其在一定的条件下能够诱导分化为神经细胞，并具有神经细胞的结构和功能，将为神经系统疾病的治疗提供新的思路。着重对骨髓基质干细胞向神经细胞诱导分化及功能方面的研究进行综述。 Bone marrow stromal cells（BMSCs） is a kind of adult stem cells which exists widely in human mesenchymat tissues and have active abilities of self-replication and multi-differentiation. When intervened individually or jointly by certain inducing agents and by the kind of genes, it can differentiate into specific lineage of cells in vitro and the capacity of muhilineage differentiation and prohferation does not change. At the same time, with the unique immunological characteristics, it is an ideal seed cell for tissue engineering. In recent years, a lot of studies have proved that BMSCs can not only be induced and differentiate into nerve cells under certain conditions but have a certain structure and function of the nerve cells, which provide a new way in the treatment of nerve system diseases.This paper gives a review of studies on induced differentiation of BMSCs into nerve cells and the functions.
作者 李鹏斌 郑启新
机构地区 华中科技大学同济医学院附属协和医院骨科
出处 《国际生物医学工程杂志》 CAS 北大核心 2009年第4期234-237,250,共5页 International Journal of Biomedical Engineering
关键词 骨髓基质干细胞 神经细胞 诱导分化 功能特征 Bone marrow stromal cells Neural cells Induction Functional characteristics
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献23

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二级参考文献29

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国际生物医学工程杂志
2009年 第4期

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