摘要
目的:探讨帕罗西汀对原发性高血压伴焦虑抑郁患者降压疗效和血压昼夜节律的影响。方法:63例原发性高血压伴焦虑抑郁症状患者,随机分为实验组(常规降压+抗焦虑抑郁剂:帕罗西汀)和对照组(常规降压+安慰剂),并随访6周,观察2组治疗前、后焦虑自评量表(SAS)和抑郁自评量表(SDS)得分、坐位血压、动态血压及血压昼夜节律变化情况,并对2组结果加以比较。结果:(1)实验组治疗后SAS、SDS评分明显降低(P<0.01),而对照组无明显变化(P>0.05),2组治疗后相比差异有统计学意义(P<0.01);(2)实验组降压有效率(71.0%)明显高于对照组(56.3%),组间比较差异有统计学意义(P<0.05);(3)2组治疗后24 h平均血压、白昼平均血压、夜间平均血压均较治疗前降低(P<0.05),但实验组较对照组更为明显,组间比较差异有统计学意义(P<0.05);并且尤以实验组夜间平均血压降低更为明显(P<0.001);(4)实验组治疗后非勺型血压昼夜节律发生率明显降低(P<0.01),而对照组无明显变化(P>0.05),2组治疗后相比差异有统计学意义(P<0.01)。结论:抗焦虑抑郁剂帕罗西汀有利于原发性高血压伴焦虑抑郁患者焦虑抑郁情绪及血压的控制,即可提高降压疗效,又可改善血压昼夜节律。
Objective： To investigate the effects of paroxetine on antihypertensive therapy and circadian rhythm of ambulatory blood pressure in essential hypertensive patients with anxiety and depression. Methods： Sixty three essential hypertensive patients with anxiety and depression were randomly divided into two groups ： experimental group （routine antihypertensive drugs and anti-anxiety depression drug ： paroxetine） and control group （routine antihypertensive drugs and VitB6）, to follow up for 6 weeks. To observe the scores of SAS/SDS, the blood pressure at base line in sitting position, ambulatory blood pressure monitorin （ABPM） and circadian rhythm of ambulatory blood pressure were compared between experimental group and control groups. Results.- （1） The SAS and SD$ of experimental group decreased in post-treatment （P 〈0.01）, but control group no changed （P 〉0.05）. There was statistical significance in two groups in post-treatment （P 〈0.01）. （2） The effective rate had statistical significance in two groups in post-treatment （71.0% to 56.3%, P〈0.05）. （3） The 24 hours average blood pressure, the average blood pressure of daytime, the average blood pressure of night of two groups decreased on post treatment （P〈0.05）, but it is significant between experimental group and control group （P〈0.05）, and the average blood pressure of night on experimental group was higher obviously （P 〈0. 001）. （4） Non-dipper day-night rhythm incidence of experimental group decreased obviously in post-treatment （P 〈 0. 01）, but control group no changed. There was statistical significance in two groups in post-treatment （P〈0.01）. Conclusion： The anti-anxiety-depression drug, Paroxetine has effect on antihypertensive therapy and circadian rhythm of amhulatory blood pressure in essential hypertensive patients with anxiety and depression, to elevate depressurization therapeutic effect, to improve day-night circadian rhythm.
出处
《新疆医科大学学报》
CAS
2009年第8期1087-1090,共4页
Journal of Xinjiang Medical University
关键词
原发性高血压
焦虑抑郁
帕罗西汀
昼夜节律
essential hypertension
anxiety deprssion
paroxetine
circadian rhythm
