摘要
目的观察静脉注射罗库溴铵时的气管插管条件、维持肌松过程和恢复过程，及其对循环的影响。方法将３２例择期手术病人，随机分为两组：Ⅰ组、Ⅱ组病人分别于静脉注射罗库溴铵后６０和９０秒钟进行气管插管。完成插管后将病人再分为两组（Ⅲ、Ⅳ组），Ⅲ组间断静脉注射罗库溴铵维持肌松，Ⅳ组连续滴注罗库溴铵维持肌松。结果静脉注射罗库溴铵０．６ｍｇ／ｋｇ（２×ＥＤ９５）后６０秒钟和９０秒钟时的气管插管条件均为优良，神经肌肉阻滞程度分别是Ｔ１为（２３±２２）％，Ｔ４／Ｔ１为（２７±２８）％（６０秒钟）和Ｔ１为（６±１０）％，Ｔ４／Ｔ为（１７±１９）％（９０秒钟），起效时间为２．３分钟。静脉注射罗库溴铵后心率、血压平稳。结论静注罗库溴铵（０．６ｍｇ／ｋｇ）后６０～９０秒钟均可为气管插管提供满意的肌松，术中间断静注或连续滴注均可维持满意的手术肌松。
Objective To assess intubating conditions after administration of rocuronium 0.6mg/kg at 60 or 90 s and neuromuscular blocking effects of rocuronium. Methods Thirty two patients were randomly designated to two groups: 60 s group and 90 s group. Anesthesia consisted of thiopentone, fentanyl,N2O/O2 and enflurane. After a 2×ED95 dose the trachea was intubated at 60 or 90s and the intubating conditions were recorded. After intubation was finished, patients were allocated randomly to receive either intravenous infusion or bolus injection of rocuronium to maintain surgical relaxation.Results Intubating conditions were not different between the two groups and were found to be clinically acceptable (good or excellent) in all patients. The maintenance of surgical relaxation was satisfactory either with repeated bolus and infusion of rocuronium. Conclusion Intubation can be performed under good to excellent conditions within 60～90 seconds after a bolus dose of 0.6mg/kg rocuronium.This indicates that rocuronium may be a suitable alternative to succinycholine during rapid sequence induction of anesthesia.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1998年第7期520-522,共3页
National Medical Journal of China
关键词
肌松弛剂
气管插管
罗库溴铵
全身麻醉
Muscle relaxants, central Endotracheal, intubation Anesthesia, general
