摘要
目的 研究微生态制剂强化的肠内营养在急性重症胰腺炎早期救治中的应用效果。方法78例急性重症胰腺炎患者采用奇偶数法随机分成强化治疗组和对照组，每组各39例。强化治疗组应用肠内营养混悬液加微生态制剂，连用1周；对照组单用肠内营养混悬液。监测肠内营养前1d和第8天两组患者内毒素（ET）、C反应蛋白（CRP）、肿瘤坏死因子α（TNF—α），白细胞介素6（IL-6）水平变化，同时测定前1d和第8天粪便中分泌型IgA（S—IgA），检测两组患者菌群失调情况并分类，并观察比较两组感染并发症的发生率。结果第8天外周ET、CRP、TNF—α）、IL-6水平强化治疗组中均低于对照组（P〈0．05），同时强化治疗组粪便中S—IgA量较对照组明显升高，感染等并发症下降，差异有统计学意义（P〈0．05），两组患者粪便中细菌油镜计数结果显示强化治疗组菌群失调患者例数明显少于对照组。结论急性重症胰腺炎患者早期应用微生态制剂强化的肠内营养可改善肠黏膜屏障功能，减少肠内营养感染性并发症的发生率，有效防止肠道菌群失调，增强患者机体免疫。
Objective To investigate the efficacy of microecopharmaceutics-supplemented enteral nutrition in early treatments of patients with severe acute pancreatitis. Methods Seventy eight patients with severe acute pancreatitis were divided into two groups： MSEN-group （39 cases） who received microecopharmaceutics-supplemented enteral nutrition emulsion for 7 d, and EN group （39cases） who received conventional enteral nutrition emulsion for 7 d. Plasma endotoxin, CRP, TNF - α and IL- 6 levels were determined at the Ist and 8th day after enteral nutrition. Results Microecopharmaceutics supplemented enteral nutrition was well tolerated. Plasma endotoxin, CRP, TNF- α and IL - 6 levels in MSEN group decreased more rapidly than those in EN group. The incidence of infections was significantly lower in MSEN group than that in EN group. The prevalence of intestinal microflora disorders in MSEN group was less than that in normal subjects and EN group. Conclusion Early enteral nutrition supplemented with microecopharmaceutics is more beneficial than conventional enteral nutrition for patients with severe acute pancreatitis.
出处
《浙江医学》
CAS
2009年第3期301-304,共4页
Zhejiang Medical Journal
关键词
微生态制剂
肠内营养
急性重症胰腺炎
Microecopharmaceutics Enteral nutrition Severe acute pancreatitis
