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高渗盐联合大剂量利尿剂在心衰并重度水肿中的应用 被引量:3

Effect of High~dose Furosamide and Small Volume Hypertonic Saline Solution Infusion in Refractory Congestive Heart Failure
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摘要 目的探讨高渗盐水合用大剂量利尿剂治疗心力衰竭的安全及有效性。方法对照组予常规抗心衰治疗,治疗组用3%高渗盐水后静滴速尿,观察比较2组疗效。结果治疗组水肿消退时间、心功能改善时间分别均显著低于对照组(P<0.05),1年内病死及心衰加重的发生率无显著差别(P>0.05)。结论高渗盐水合用大剂量利尿剂治疗顽固性心力衰竭并低钠血症安全有效,但不能改善患者预后。 Objective To observe the effect of hypertonic saline solution infusion in refractory congestive heart failure. Methods Patients in control group got routine therapy; Patients in hypertonic saline treated group were treated by high--dose furosamide and small volume hypertonic saline solution infusion besides routine therapy. Results It took less time for heart function to be improved in patients of hypertonic saline treated group than that in control(P〈0.05).However the rates of death in 1 year and the deterioration of the heart function were not significantly different between two groups. Conclusion High--dose furosamide and small volume hypertonic saline solution infusion is effective in patients with refractory heart failure, but can not improve their prognosis.
出处 《中外医疗》 2009年第25期4-5,共2页 China & Foreign Medical Treatment
关键词 呋噻米 高渗盐水 心力衰竭 Hypertonic saline solution Furosamide Heart Failure
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参考文献3

  • 1Patema S, Di Pasquale P, Parrinelb G,et al. Effect of high-dose furosamide and small volume hypertonic saline solution infusion in comparison with a high dose of furosemide as bolus,in refrac- tory congestive heart failure[J]. Eur J Heart Fail, 2000,2(3):305- 313.
  • 2张清潭,李宗清,李明娥,石斗飞,曹庆博,张子彬.高渗盐水合并大剂量呋噻米治疗难治性心力衰竭临床研究[J].山东医药,2007,47(19):89-90. 被引量:4
  • 3Licata G,Di Pasquale P, Parrinelb G,et al. Effect of high-dose furosamide and small volume hypertonic saline solution infusion in comparison with a high dose of furosemide as bolus in refractory congestive heart failure: long-term effects[J].Am Heart J,2003, 145(3):459- 466.

二级参考文献5

  • 1Licata G,Di Pasquale P,Parrinello G,et al.Effect of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as bolus in refractory congestive heart failure:long-term effects[J].Am Heart J,2003,145(3):459-66.
  • 2Paterna S,Di Pasquale P,Parrinello G.Effect of high-dose furosemide and small-volume hypertonic saline solution infusion in comparison with a high dose of furosemide as a bolus,in refractory congestive heart failure[J].Eur J Heart Fail,2000,2(3):305-313.
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  • 4McCullough PA,Nowak RM,McCord J,et al.B-type natriuretic peptide and clinical judgement in emergency diagnosis of heart failure ∶ analysis from Breathing Not Properly (BNP) Multinational study[J].Circulation,2002,106 (4):419-422.
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