摘要
目的探讨脑心通胶囊与他汀类药物联合治疗对胸痹心痛(冠心病、心绞痛)患者临床症状、心电图及颈动脉粥样硬化等相关因素的影响。方法采用随机单盲平行对照的方法分析92例胸痹心痛(冠心病、心绞痛)患者临床资料,并进行统计学分析。92例中,脑心通加辛伐他汀治疗45例(治疗组),消心痛加辛伐他汀治疗47例(对照组)。结果两组共计治疗18个月。两组临床症状治疗效果:治疗组总有效率93.3%,对照组总有效率80.9%。两组间总有效率比较,经Ridit检验,治疗组与对照组分别为R=0.36和R=0.62,差异有显著性(P<0.05);治疗组总胆固醇(TC)、甘油三酯(TG)低密度脂蛋白胆固醇(LDC-C)以及颈动脉内-中膜厚度(IMT)均有降低,动脉粥样硬化斑块明显改善,与对照组比较差异有显著性(P<0.05)。结论脑心通胶囊联合辛伐他汀能明显缓解胸痹心痛患者的临床症状,改善心电图缺血,且能逆转动脉粥样硬化斑块。TC、TG、LDC-C、IMT的明显改善。
Objective To observe the curative effect of combined. Naoxintong and statins for in precordial pain chest - Bi （ angina pectoris in coronary heart disease）. Methods 92 patients of precordial pain in chest - Bi （ angina pectoris in coronary heart disease） were randomly divided into the combination of Naoxintong and simvastatin （treatment group n =45 ）and isosorbide dinitrate and simvastatin（ control group n = 47）. Two groups were administered separately for 18 months. The values of the different syndrome, ECG,TC ,TG, LDC - C and carotid artery thickness were compared before and after administration. Results Active ratio is 93. 3% in treatment group with improvement of clinic syndrome. Other total efficiency after 18 months was as follows： TC,TG, LDC -C decreased to normal,and electro cardiogram and carotid atherosderosis in the treatment group improved significantly（ P 〈 0. 05 ）, compared with that before treatment. Conclusion It is effective and safe to treat precordial pain in chest - Bi with the combination naoxintong and simvastatin.
出处
《中国医学创新》
CAS
2009年第25期10-12,共3页
Medical Innovation of China
关键词
胸痹心痛
脑心通
他汀类
辛伐他汀
Precordial pain in chest- Bi
Naoxintong
Statins
Simvastatin
