摘要
传统中药两面针(Zanthoxylum nitidum(Roxb.)DC)有效成分氯化两面针碱主要通过抑制拓扑异构酶活性、阻滞细胞周期、诱导肿瘤细胞凋亡、逆转肿瘤细胞多药耐药等几种作用机制达到抗肿瘤作用。作为传统中药的新用法,氯化两面针碱抗肿瘤作用具有很大的开发应用价值,建议今后重点对氯化两面针碱系统的构效关系和结构优化,为研究开发新药提供目的化合物或候选药物分子;同时通过合成和建立天然活性物质类似物的化合物库来研发新药。
Nitidine Chloride （NC） is Zanthoxylum nitidum （Roxb.） DC. the effective constituent of the traditional Chinese medicine The mechanisms of its anti-tumor effect are related to inhibiting the activity of topoisomerase, arresting cell cycle, inducing apoptosis of tumor cells, and reversing tumor cells multidrug resistance. NC has high value in the research of cancer therapy. Therefore, by studying the structure-function relationship and structural modification of NC should be one of the hotspots in the future and may supply the purpose-compound and medicine-molecule for the research and development of new drugs. Meanwhile, by synthesizing and establishing the pool of natural active compound analogs will be another potential method for us to research new drugs.
出处
《广西科学院学报》
2009年第3期187-191,共5页
Journal of Guangxi Academy of Sciences
基金
广西科学研究与技术开发计划项目(No.桂科攻0630002-2E)资助
关键词
两面针
氯化两面针碱
抗肿瘤作用机制
Zanthoxylum nitidum （Roxb.） DC,nitidine chloride,antitumour mechanism
