摘要
为探讨前列环酸（ＰＧＩ２）和血栓素（ＴＸＡ２）与先兆早产的关系，采用放射免疫法分别测定了先兆早产和足月临产孕妇血及宫颈粘液中６－酮－ＰＧＦ１α、ＴＸＢ２和孕酮的浓度，并与相对应孕周的孕妇进行比较。结果：与对照组相比，先兆早产组及足月临产组的血浆ＴＸＢ２和６－酮－ＰＧＦ１α水平明显升高（Ｐ＜０．００１），６－酮－ＰＧＦ１α／ＴＸＢ２比值降低（Ｐ＜０．００１），而孕酮水平则无显著性差异（Ｐ＞０．０５）；粘液中的结果与血一致。由此提示：ＰＧＩ２、ＴＸＡ２和ＰＧＩ２／ＴＸＡ２比值（ＴＸＡ２升高得更多）与先兆早产和足月临产的发生有关。先兆早产和足月临产之孕酮水平与对照组无差异，孕酮局部的撤退或下降可能在生产的发动中起作用。
The objectives of this study were to investigate the levels of 6ketoPGF1α, TXB2 and progesterone in plasma and cervical mucus of women with threatened preterm labor (Group Ⅰ), term labor (Group Ⅲ) versus their controls (Groups Ⅱ and Ⅳ) respectively and to investigate the relationship between these substances and threatened preterm labor. One case was matched with one control (pregnant woman )by weeks of gestation. Radioimmunoassay was used to determine the levels of 6ketoPGF1α, TXB2 and progesterone. Statistical differences were assessed by student t test. The results showed that the levels of TXB2, 6KetoPGF1α in plasm from women with term labor and threatened preterm labor were higher than those of the control groups (P<0.001) respectively. The ratios of 6ketoPGF1α and TXB2 were lower than their controls (P<0.001) respectively. No differences in the levels of progesterone were noted between the labor groups and their control groups (P>0.05) respectively. The results observed in cervical mucus were in line with there in plasma. These results suggest that the lovels of PGI2, TXA2, and PGI2/TXA2 ratio were associated with the onset of term labor.
出处
《华西医科大学学报》
CSCD
1998年第3期315-319,共5页
Journal of West China University of Medical Sciences
关键词
先兆早产
前列环酸
血栓素
孕酮
早产
Threatened preterm labor Term labor PGI2 TXA2 Progesterone
