摘要
采用免疫组织化学方法对６１例不同类型的白血病细胞检测了ｐ１６基因产物ｐ１６蛋白的表达。在白血病中，ｐ１６蛋白表达减低或阴性者占５７４％，其中在髓系白血病中占４３６％，在淋系白血病中占７６５％，两组具有显著性差异（Ｐ值为０１５９）。ｐ１６蛋白表达量与ｐ５３蛋白表达量、患者年龄、血红蛋白、白细胞、血小板间无显著性相关。在白血病病人中存在有ｐ１６蛋白表达的减低。
出处
《中国实用内科杂志》
CSCD
北大核心
1998年第9期535-356,共1页
Chinese Journal of Practical Internal Medicine
参考文献6
-
1Marx J .A chalenge to P16 gene as a major tumor suppressor.Science,1994;264:1846.
-
2Igaki H,Sasaki H.Tachimori Y,et al.Mutation frequence of the P16/CDKN2 gene in primary cancer in the upper digestive tract.Cancer Res.1995,55:3421.
-
3Ogawa S,Hangaishi A,Miyawaki S.et al.Loss of the cyclin-dependent kinase-4 inhibitor(P16;MTS1)gene is frequent in and highly specific to lymphoid trmor in primary human hematopotic malignancies.Blood ,1995,86:1548.
-
4Delmer A,Tang R,Senamaud-Beaufort C,et al.Alterations of cyclin-dependent kinase-4 inhibitor(P16INK4A/MTS1)gene structure and exprssion in acute lymphoblastic leukemia.Leukemia,1995;9:1240.
-
5Takeuchi S,Bartram CR,Seriu T,et al.Analysis of family of cyclin-dependent kinase inhibitrcs;P15/MTS2/INK1B,P16/MTS1/INK4A,and P18 gene in acute-lymphoblastic leukemia of childhood.Blood,1995;86:755.
-
6Cruis NA,Weaver-Feldhaus J,Liu QY,et al.Evidence in melanoma and bladder cancers that P16 and P53 function is seperate pathways of tumor suppression.American Journal of Pathology,1995;146:1199.
同被引文献21
-
1乐蓓蓓,陈燕,喻东姣,宋晓华,向直富,向建平,李崇渔.急性白血病的P16基因表达分析[J].中国组织化学与细胞化学杂志,1998,7(2):179-183. 被引量：2
-
2Serrano M . The tumor suppressor protein P16INK4a[J]. Exp Cell Res. 1997,237:7-13.
-
3William H, Liggett Jr,David Sidransky et al Role of the P16 Tumor suppressor Gene in cancer[J]. Cancer Research. 1998,16(3): 1197-1206.
-
4Moller-MB,Ino-Y.Aberatios of the P53 pathway Components P53,MDA2,CN2A appear inerpendent in diffuse large Bcell lymphoma[J].Lenkemia.1999,13(3):453-459.
-
5Cambart AF, Morosetti R. Deletion of the cyclin dependent kinase inhibitor genes P16 and p15 in non - Hodgkins lymphomas[J]. Blood,1995,86:1534-1539.
-
6Tam-Sw, Shay-JW, Pageno M. et al. Differential expression and cell cycle regulation of the cyclinD- Dependent kinase 4 inhibitor p16[J]. Cancer Res.1994,54(22):5816-5820.
-
7Hebert J, Cayula JM, Berkeley J, et al. Candiate tumor suppressor gene MTS1(P16) and MTS2(p15) display frequent homozygous deletion in primary cells From T-but not from B-cell lineage acute lymphoblastic leukemia[J]. Blood.1994, 84(12) :4038.
-
8Fizzotti M, Cimio G. Detection of homozygous deletion of the cyclin -dependent kinase 4 Inhibitor (P16) gene in acute lymphoblastic leukemia and association with adverse prognostic features[J]. Blood.1995, 85(10) :2685.
-
9Rasool O, Heyman M. p15 and P16 gene inactivation in acute lymphocitic leukemia[J].Blood.1995, 85(12):3431.
-
10Quesnel B, Preudhomme C. P16 gene homozygous deletion in acute lymphoblastic leukemia[J]. Blood.1995,85(3): 657.
-
1温雪萍,程西安,苏宝山.P_(16)基因产物在肺癌中的表达及其临床意义[J].西安医科大学学报,1999,20(2):209-212.
-
2化罗明,郭明,程茂清,郝书香,王四宝,杜新杰,张瑞芳,左连富.应用FCM检测白血病细胞P_(16)基因产物的表达及其临床意义[J].临床医学,1999,19(6):6-7.
-
3张茹慧,葛兮源,张颖奇.p27及p16蛋白在口腔鳞癌中的表达和意义[J].临床口腔医学杂志,2003,19(7):397-399.
-
4郭卫平,王陆林,谢志征.p53、p16在胆囊癌的表达及其临床意义[J].河南外科学杂志,2000,6(2):107-108.
-
5黄学胜,刘锟,王云杰,马乃绪,王丽,田德明.抑癌基因p16在肺癌中的表达及意义[J].中国胸心血管外科临床杂志,1997,4(2):70-72. 被引量：8
-
6王志新,陈维中.p16基因产物在非小细胞肺癌表达及意义[J].中国癌症杂志,1999,9(3):209-210.
-
7王允,任莉,吕重九,罗德元,陈晓峰,陈军,周清华.人非小细胞肺癌中p16基因产物表达研究[J].中国胸心血管外科临床杂志,1997,4(3):154-156. 被引量：8
-
8刘刚,李金荣,张文峰,杨学文,严全梅.口腔鳞癌p16基因的表达及其病理意义[J].口腔颌面外科杂志,2001,11(2):119-121. 被引量：2
-
9马冬春,疏元善,魏大中,范军,戎保林,吴双正.p16基因产物在肺癌中的表达研究[J].安徽医科大学学报,2000,35(1):30-32. 被引量：1
-
10乐晓峰,杨天楹.微量残留白血病细胞检测的研究进展[J].中华血液学杂志,1992,13(3):155-157. 被引量：1
