摘要
目的通过卡介苗对儿童结核性脑膜炎(结脑)和粟粒性结核保护效果的系统评价,为完善卡介苗免疫策略提供依据,为开展效果研究提供线索。方法采用系统评价方法,以卡介苗、结脑、粟粒性结核为检索词,全面检索中国医院知识数据库(China Hospital Knowledge Database,CHKD)期刊全文库(1979～2007年)、CHKD会议论文全文数据库(1999～2008年)和万方学术期刊数据库(1982～2007年),对纳入文献相关信息进行分析。结果符合纳入标准的文献28篇,1篇涉及粟粒性结核,25篇涉及结脑,2篇既涉及结脑又涉及粟粒性结核。卡介苗对结脑发病的保护效果系统评价显示:生态学研究均认为卡介苗对结脑的发病有保护作用;结脑病例中接种卡介苗所占的比例差别较大(0～69.08%),粟粒性结核卡介苗未接种的比例为17.24%。Mete分析卡介苗对结脑的保护效果为81%,95%可信区间为57%～91%。结论接种组与未接种组的对照研究显示,卡介苗对预防结脑有保护效果。粟粒性结核保护作用研究的文献少,无法得出确切结论。
Objective To Understand the protective effi cacy of Bacillus CalmetteGuerin （BCG） vacciation against children tuberculosis meningitis and millet tuberculosis,to provide the data to improve immune tactics of BCG. Methods A search CHKD full text database （1979～2007） and CHKD meeting paper database （1999～2008） and WANGFANG database （1982～2007）,with BCG,tuberculosis meningitis,millet tuberculosis,then to analyze information from qualif ied literatures. Results 28 paper were involved. 25 were correlated with tuberculosis meningitis,1 correlated with millet tuberculosis,2 correlated with both. The study about protections of BCG against tuberculosis meningitis showed that BCG has protective action in ecology study. The inoculation of BCG in tuberculosis meningitis cases was 0～69.08%,millet tuberculosis BCG inoculating with 82.76%. Result of Mete analysis showed that it was 81% to the protection tuberculosis meningitis,95% CI is 57%～91%. Conclusion BCG vaccine has protective effect for prevent.ing tuberculous meningitis. Due to lack of case-control study,cases in vaccinated and unvaccinated ratio should not an objective description of the effect of BCG vaccination. Protective effect of miliary tuberculosis research literature was less,unable to come to precise conclusions.
出处
《中国疫苗和免疫》
CAS
2009年第4期358-362,共5页
Chinese Journal of Vaccines and Immunization
关键词
卡介苗
结核性脑膜炎
粟粒性结核
效果
系统评价
Bacillus calmette guerin
Tuberculosis meningitis
Millet tuberculosis
Effect
Systematic review
