摘要
目的研究血清脂蛋白（a）水平与脑梗死的关系。方法选取2007年1月～2008年12月在本院神内科住院治疗的100例脑梗死患者作为观察组,选取同时期在体检中心进行健康体检的100例健康成人作为对照组,对两组受试者分别检测LP（a）的水平,观察LP（a）水平与缺血性脑血管疾病的关系。结果观察死组血清LP（a）水平显著高于对照组（P〈0.05）;观察组的各种亚型中,大、中面积的脑梗死组血清LP（a）水平显著高于对照组（P〈0.05）,腔梗组和对照组比较差异无统计学意义（P〈0.05）。脑梗死组的前后循环亚组血清LP（a）水平显著高于对照组（P〈0.05）,前后循环亚组之间差异无统计学意义（P〈0.05）。Logistic回归分析显示：血清LP（a）水平与脑梗死的发生有一定的相关性。结论血清LP（a）水平升高可能是缺血性脑卒中的重要危险因素之一,主要和脑部大、中动脉梗死相关,和腔隙性梗死无明显相关性。
Aim To detect the correlation between serum lipoprotein（a）level and cerebra infarction（CI）.Methods 100 cases were selected from the stroke（CI） patients at the neurology department from Jan.2007 to Dec.2008.The control group（100 cases） is selected from healthy adults at the same period.The serum lipids concentration of LP（a） were assayed by enzyme-linked immunosorbend.Results The serum LP（a） lipid level is significantly increased in CI patients rather than control group（P〈0.05）;Among all subtypes of CI, the LP （a） level is significantly increased in large and medium vessels groups than in control group （ P 〈 0.05 ）, the data of lacunar infarct and control group patients has no statistical difference（P 〉0.05）The LP（a） level of the anti-circulation and post -circulation group of C! is significantly increased rather than control group （ P 〈 0.05 ）, but the difference between them has no statistical difference （ P 〉 0. 05 ）. Logistic regression analysis shows high level of serum LP（a） might be an important dangerous factor to ischemic stroke. Conclusion The high level of serum LP（a） might be one of the important dangerous factors to ischemic stroke, especially to large and moderate vessels, it has no statistical difference compared to lacunar infarct.
出处
《安徽医药》
CAS
2009年第8期934-935,共2页
Anhui Medical and Pharmaceutical Journal
