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CD34与MVD在宫颈上皮瘤样变及鳞癌中的表达与临床预测价值

Expression of CD34 and MVD protein and its correlation with neovasculari zation in cervical squamous cell carcinoma and CIN
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摘要 目的探讨宫颈上皮瘤样变及鳞癌组织中CD34与MVD的表达及其与肿瘤血管新生的关系,为宫颈鳞癌的抗血管新生治疗及宫颈上皮瘤样变的临床预后判断提供实验依据。方法采用免疫组织化学S-P法检测宫颈鳞癌Ⅰ期13例,Ⅱ期9例,Ⅲ期1例;宫颈上皮瘤样变组织60例(其中CINI级30例,CINII级30例,CINIII级(原位癌)30例);正常宫颈上皮组织30例的CD34与MVD的表达。结果宫颈鳞癌不同临床分期及宫颈上皮瘤样变不同分级中CD34的阳性率、MVD数值差异有统计学意义(P<0.05)。结论联合检测CD34和MVD可以更好地为宫颈上皮瘤样变及宫颈癌临床判断预后及抗新生血管治疗提供参考依据,具有较重要的临床预测价值。 Aim To investigate the expression of CD34 and MVD protein and its correlation with neovascularization in cervical squamous cell carcinoma and CIN,so as to provide experimental foundation for prevention and therapy forecast of CIN.Methods The expression of CD34 protein and microvascular density（MVD） labeled by CD34 were examined by immunohistochemistry S-P method in 23 cases of CSCC and 90 cases of CIN and 30 cases of normal cervical epithelium.Result The expression of CD34 protein and MVD was significantly higher in CSCC than that in CIN and normal cervical epithelium （ P 〈 0.01 ）. Overexpression of CD34 protein and MVD in CIN were related to CIN grade. The MVD was significantly higher in the CD34 protein positive tumors than in negative ones （ P 〈 0.05 ） .Conclusion The expression of CD34 and MVD can be helpful in forecasting prognosis and therapy of cervical squamous cell carcinoma and CIN.
作者 潘维君 程正兰
机构地区 安徽省马鞍山市妇幼保健院妇产科
出处 《安徽医药》 CAS 2009年第8期904-906,共3页 Anhui Medical and Pharmaceutical Journal
关键词 宫颈上皮瘤样变 宫颈鳞癌 CD34 MVD 免疫组织化学 CIN cervical squamous cell Carcinoma CD34 MVD immunohistochemistry
分类号 R737.33 [医药卫生—肿瘤]
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安徽医药
2009年 第8期

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