摘要
目的:以氟康唑为先导化合物,设计合成新的三唑醇类化合物,并研究其抗真菌活性。方法:引入环己基侧链结构,合成一系列目标化合物,所有化合物结构均经MS、1H-NMR等谱确证;选择8种真菌为实验菌株,测定其体外抗真菌活性。结果:合成了11个未见文献报道的目标化合物,部分化合物对所选真菌均表现出了一定的抑菌活性。结论:引入环己基对抗真菌活性影响较大。
Objective ： Design and synthesis of novel triazole antifungal derivatives based on the structure of fluconazole. Methods ： A cyclohexyl group introduced and a series title compounds synthesized All of them were confirmed by MS, 1 H-NMR, et al. The anti- fungal activities were also evaluated against the eight common pathogenic fungi. Results：Eleven title compounds were synthesized. Some of the title compounds exhibited activity against fungi tested to some extent. Conclusion ： A cyclohexyl group introduced to the side chain affected the antifungal activity.
出处
《药学实践杂志》
CAS
2009年第4期266-269,共4页
Journal of Pharmaceutical Practice
基金
国家自然科学基金资助项目(NO.20772153)
上海市重点学科资助项目(NO.B906)
