摘要
目的:探讨奎硫平与利培酮治疗老年精神分裂症的效果与不良反应。方法:将60例老年精神分裂症患者随机分为奎硫平治疗组和利培酮治疗组,每组各30例,进行临床对比研究,疗程均为8 w。于治疗前及治疗第1、2、4、8周末采用阳性与阴性症状量表评价临床疗效、副反应量表评价不良反应。疗效标准:以阳性与阴性症状量表减分率≥75%为痊愈,50%～74%为显著性进步;25%～49%为好转,<25%为无效。结果:奎硫平治疗有效率为90.0%,利培酮治疗有效率为83.3%,两组比较差异无显著性。奎硫平组锥体外系不良反应明显少于利培酮组,其它不良反应因子两组比较差异均无显著性(P>0.05)。结论:奎硫平治疗老年精神分裂症疗效肯定,不良反应少,依从性好。
Objective：To explore the efficacy and safety of quetiapine in the treatment of schizophrenia. Methods：60 schizo- phrenics who met the CCMDIII criteria for schizophrenia were randomly assigned to the quetiapine （ n = 30） and risperidone （ n = 30） groups for 8 week. Curative effects were assessed with the Positive And Negative Rating Scale（ PANSS）, and side effects with the Treatment Emergent Symptom Scale（TESS） before treatment and at the ends of 1st ,2nd ,4th and 8th week of treatment. The criteria of curative effects; scorereducing rate of the PANSS ≥75% was recovery, ≥50% significant improvement, ≥25% improvement and 〈 25% ineffectiveness. Results： The effective rate of qutiapine was 70.0% and risperidone 66.7%, which showed no significant difference. Extrapyramidal side effects of quetiapine were fewer than those of risperidone, there was no obvious difference in other factors of side effects between the 2 groups （ P 〉 0.05）. Conclusions ： Quetiapine has better curative effect, fewer side effects and better compliance in the treatment of schizophrenia.
出处
《中国民康医学》
2009年第17期2100-2101,共2页
Medical Journal of Chinese People’s Health
