摘要
目的：探讨有机合成川芎哚的方法。方法：以糠醇、色氨酸为原料（路线１）和以糠醇、色胺为原料（路线２）两种途径，经多步反应合成川芎哚。结果：路线１制备川芎哚的终产率为７％，其结构经ＵＶ，ＩＲ，ＭＳ和ＮＭＲ确证；路线２制备川芎哚的终产率为１２％，其结构经ＭＳ，ＵＶ确证。结论：两种合成路线都适于合成川芎哚，但路线２的产率高于路线１。
OBJECTIVE: To isolate bioactive polysaccharides from Panax quinquefolium L. and determine its sugar composition, uronic acid content, molecular weight and biological activities. METHODS: Sephadex DEAE A50 and Sephadex G100 chromatography were used. The sugar composition was analyzed by gas chromatography. The molecular weight was determined by matrix assisted laser desorption/ionization mass spectrometer (MALDIMS). RESULTS: Isolated PPQ52 was composed of Darabinose and Dgalactose in a molar ratio of 1∶1.1. It contained uronic acid. The average molecular weight was 21 000 Dalton. It stimulated the transformation of lymphocyte and induced the production of IL2. CONCLUSION: Immunologically active ploysaccharide could be obtained from Panax quinquefolium L.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1998年第8期492-492,共1页
Chinese Pharmaceutical Journal
基金
高等学校博士学科点专项科研基金
国家自然科学基金
关键词
川芎哚
心血管药物
有机合成
Panax quinquefolium L., polysaccharide, matrix assisted laser desorption/ionization mass spectrometry, interleukin2
