摘要
目的:检测中性粒细胞弹性蛋白酶(NE)在银屑病患者皮损及血清中的表达。方法:用双抗体夹心ELISA法,检测50例寻常性银屑病患者和16例脓疱性银屑病患者外周血,以及32例寻常性银屑病患者和10例局限性脓疱性银屑病患者皮损负压吸疱液中NE表达水平。结果:寻常性银屑病患者外周血及皮损组织液中NE表达水平显著高于对照组(P均<0.01),其中进展期和稳定期寻常性银屑病患者外周血及皮损组织液中NE的表达差异有统计学意义(P<0.05),且与患者相应的银屑病皮损面积和严重度指数(PASI)积分呈正相关。脓疱性银屑病患者外周血及皮损组织液中NE表达水平与对照组相比,差异有统计学意义(P<0.05)。结论:NE在寻常性银屑病和脓疱性银屑病发病机制中可能起重要作用。
Objective： To detect the expression of neutrophil elastase in psoriasis. Methods： The expression of neutrophil elastase was measured with double-sandwich ELISA. The specimens measured were the sera from 50 patients with psoriasis vulgaris and 16 patients with pustular psoriasis, and the suction blister fluids from 32 patients with psoriasis vulgaris and 10 patients with circumscribed pustular psoriasis. Results： The levels of neutrophil elastase in the sera and lesions of the patients with psoriasis vulgaris were statistically higher than those from the healthy controls （P〈0.01, a11）. The expression of neutrophil elastase in the sera and lesions was statistically different between the patients during progressive stage and those during stationary stage（P〈0.05）, which was positively correlated to the psoriasis area sererity index scores in these cases. The levels of neutrophil elastase in the sera and lesions of the patients with pustular psoriasis were statistically higher than those of healthy controls（P〈 0.05）. Conclusions： Neutrophil elastase might play an important role in the pathogenesis of psoriasis vulgaris and pustular psoriasis.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2009年第9期553-555,共3页
Journal of Clinical Dermatology
