摘要
目的：探讨芳烃羟化酶（AHH）与肺癌遗传易感性的关系。方法；采用AHH直接规定法检测肺癌患者40例、肺癌患者亲属26例及健康人物例血液淋巴细胞中AHH的诱导力。结果：①肺癌组及肺癌患者亲属（一级亲属24人，二级亲属2人）高AHH诱导力型升高（22．5％，15．4％），肺癌组高AHH诱导力型与对照组（6．7％）相比有上升趋势（P＝0.12，x2检验）。②不吸烟者中，肺癌组、肺癌患者亲属及对照组高AHH诱导力者分别达15．4％、ZI％、7．3％，肺＃患者亲属高AHH诱导力型有上升趋势（P二0．2）。③肺癌的相对危险性（OR）与淋巴细胞中AHH的诱导力有关，肺癌亲属中高AHH诱导力的OR值是低AHH诱导力者的2．1倍。结论：肺癌具有遗传易感性，与AHH诱导力密切相关。
In order to investigate the relationship between aryl hydrocarbon hydroxylase (AHH( inducibility and geneticsusceptibility on lung cancer, the AHH inducibility in lymphocyte has been measured in 45 healthy individuals, 40 patients withlung cancer and 26 relatives of them.The results were as follows: ①AHH high inducibility in lung cancer patients was increased(22.5%,P=0.12);AHH high inducibility in their relatives was increased, too ( 15.4%,P>0.05);②AHH high induibilityin nonsmokers (healthy controls , patients with lung cancer and their relatives)were 7.3% ,15.4% and 21% respectively . AHHhigh inducibility in the relatives of lung cancer patients was increased (P=0.2);③A strong correlation was observed betweenAHH inducibility and the patients with lung cancer and their relatives. The odds ratio (OR)to develop lung cancer in relatives oflung cancer patients with high AHH inducibility had 2.1-fold higher than low AHH inducibility. There were genetic susceptibil-ity in development of lung cancer, which was associated with high AHH inducibility.
出处
《广东医学》
CAS
CSCD
1998年第8期567-568,共2页
Guangdong Medical Journal
基金
1995年广东省医药卫生科研基金
关键词
肺癌
遗传易感性
芳烃羟化酶
Lung nepolasms
AHH inducibility
Genetic susceptibility
