摘要
目的：建立颞下颌关节骨关节病动物模型。方法：将不同浓度乳酸脱氢酶（ＬＤＨ）一次性注入两组兔双侧颞下颌关节上腔内，分别于注射后２４ｈ，１、４、８、１２周后处死动物，对颞下颌关节标本采用组织病理学及扫描电镜观察。结果：注射ＬＤＨ４周后出现关节表面软骨破坏，关节盘胶原纤维暴露，滑膜慢性炎症等骨关节病表现。结论：本实验建立的颞下颌骨关节病动物模型可用于颞下颌关节骨关节病早、中期病变的研究。
Objective: To establish an animal model of osteoarthrosis(OA) in the temporomandibular joint (TMJ) (TMJOA) by injecting lactate dehydrogenase (LDH) into the upper compartments of TMJs in adult rabbits. Methods:Adult New Zealand white rabbits were randomly divided into four groups of five animals each. A and B groups were used as control. In group C and D LDH was injected into the upper compartments at two different concentrations at a volume of 0.1mL. The samples of TMJs were analyzed histologically and SEM in four different times after injection. Results:The animals which had injected LDH at two different concentrations resulted in similar consequence. The TMJs occurred typical changes of OA. The damages were in early to moderate stage. No pathological changes could be found in TMJs of the control groups. Conclusion:The results suggest that LDH may be of use in establishing the animal model of TMJOA.
出处
《中山医科大学学报》
CSCD
1998年第3期172-174,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
广东省自然科学基金
关键词
乳酸脱氢酶
颞下颌关节疾病
疾病模型
lactate dehydrogenase/adverse effects
temporomandibular joint diseases/chemically induced
disease models, animal
