摘要
目的对比观察普罗帕酮、胺碘酮治疗和预防阵发性心房颤动(PAF)的疗效和安全性。方法对80例阵发性心房颤动患者随机应用普罗帕酮(32例)、胺碘酮(28例)和安慰剂(20例)治疗及预防复发,治疗不少于3个月。结果三组服药后48h内转复率分别为72.7%、42.1%、23.1%,普罗帕酮组显著高于胺碘酮组和安慰剂组(P<0.05和P<0.01);随访(21.6±8.0)个月,总有效率分别为62.5%、71.4%、15.0%,两药物治疗组疗效差异无统计学意义(P>0.05),均明显优于安慰剂组(P<0.01);在随访期限>12个月的病例中,胺碘酮组有效率显著高于普罗帕酮组(P<0.05),表明胺碘酮预防阵发性心房颤动复发的远期疗效优于普罗帕酮。普罗帕酮组和胺碘酮组的不良反应发生率分别为18.8%和17.9%,对比差异无统计学意义(P>0.05),均未见严重毒副反应及致心律失常作用。结论两药对治疗和预防PFA复发性均有较好疗效,且相对安全,胺碘酮的短期复律疗效低于普罗帕酮,但预防PAF复发的远期疗效优于普罗帕酮。
Objective To investigate the efficacy and safety of propafenone and amiodarone in treating and preventing paroxysmal atrial fibrillation（PAF）. Methods 80 patiens with atrial fibrillation were divided into propafenone group（ n = 32）, amiodarone group（ n = 28 ） and placebo group （ n = 20 ） randomly. Each was treated for more than 3 moths. Results Within 48 hours after treatment the recovery rates in propafenone group, amiodarone group and placebo group were 72.7 % ,42.1% and 23.1%, respectively. The response rate of propafenone group was higher than that of the other two groups（ P 〈 0.05 ）. The follow-up period was 21.6 ± 8.0 months, and the total response rates were 62.5% ,71.4% and 15.0%, respectively. No significant difference was found between the propafenone group and amiodarone group, but the rate in the two groups was much higher that in the placebo group（P 〈 0.01 ）. After more than 12 months＇ follow-up, the response rate of amiodarone group was superior to the propafenone group（P 〈0.05）. The occurrence rates of adverse reactions in the propafenone group and amiodarone group were 18.8% and 17.9% respectively, there was no significant difference （ P 〉 0. 05 ）. No serious side-effects or arrhythmia were found. Conclusiou Both drugs were effective and relatively safe in the treatment and prevention of the relapse of PAF. The efficacy of amiodarone is lower in short-term recovery but higher in long-term prevention of recurrence.
出处
《中华全科医学》
2009年第10期1066-1068,共3页
Chinese Journal of General Practice
关键词
普罗帕酮
胺碘酮
心房颤动
阵发性
Propafenone
Amiodarone
Paroxysmal atrial fibrillation
