摘要
目的:观察5-脂氧合酶(5-lipoxygenase,5-LOX)在涎腺黏液表皮样癌(mucoepidermoid carcinoma,MEC)中的表达,探讨其作为诊治涎腺MEC生物学指标的可能性。方法:应用免疫组织化学EliVisionTMplus方法,检测5-LOX在40例涎腺MEC、20例多形性腺瘤和20例癌旁正常组织中的表达并统计分析。结果:5-LOX在涎腺MEC中表达率为67.5%,显著高于多形性腺瘤0.0%和癌旁正常组织5.0%(P<0.01),5-LOX在高、中、低分化涎腺MEC中的阳性率分别为50.0%、6/9和100.0%,肿瘤分化程度间差异有统计学意义(P<0.05)。结论:5-LOX可能是涎腺MEC诊断和判断分化程度的生物学参考指标之一。
Objective：To study the expression of 5-1ipoxygenase （5-LOX） in mucoepidermoid carcinoma （MEC）, and to explore its probability of acting as a referential index in the diagnosis and treatment of mucoepidermoid carcinoma. Methods： The expressions of 5-LOX in 40 cases of MEC, 20 cases of normal tissue of salivary glands and 20 cases of pleomorphie adenomas were detected by EliVision^TM plus immuniohistochemical method. All the data were analyzed statistically. Results ： The positive staining rate of 5-LOX in mucoepidermoid carcinoma was 67.5% ,which was significantly higher than that in pleomorphic adenoma（0.0% ） and normal tissue of salivary glands （ 5.0% ） （ P 〈 0.01 ）. The positive staining rates of 5-LOX in high-differentiated, moderate-differentiated and low- differentiated cases of MEC were 50.0%, 6/9 and 100.0%, respectively. The difference was significant （ P 〈 0.05 ）. Conclusions ： 5-LOX may be used as a biology referential index in diagnosing and differentiating the degree of mucoepidermoid carcinoma.
出处
《蚌埠医学院学报》
CAS
2009年第8期666-668,共3页
Journal of Bengbu Medical College
