摘要
麻黄碱和伪麻黄碱是药用植物麻黄的主要生物碱类次生代谢产物,具有重要的药用价值。中国是世界上惟一通过天然植物提取麻黄碱的国家,该文简述了近年来利用微生物半转化、微生物直接转化和重组微生物制备麻黄碱的研究进展,对各自存在的问题进行了讨论,展望了微生物在麻黄碱和伪麻黄碱生物合成中的应用前景。
The l-ephedrine and d-pseudoephedrine are the main alkaloid secondary metabohtes of Epheclra spp.,which have important medic-inal value.China is the only country in the world extracting l-ephedrine and d-pseudoephedrine from uncultivated plants.The research progresses of l-ephedrine and d-pseudoephedrine production by microbial senti-transformation,microbial directly transformation and recombi-nant strain were outlined,and the problems of these methods were discussed,and the prospective application of l-ephedrine and d-pseudo-ephedrine biosynthesis by microorganisms was ouflooked in this paper.
作者
凌海秋
毛培宏
金湘
吕杰
武宝山
LING Hai-qiu;MAO Pei-hong;JIN Xiang;LV Jie;WU Bao-shan(Center of Ion Beam Biotechnology,College of Physies Science and Technology,Xinjiang University,Urumgi 830008;College of Life Science and Pharmacy,Nanjing Univeraity of Technology,Nanjing 210009,China)
出处
《生物技术》
CAS
CSCD
北大核心
2009年第4期94-95,共2页
Biotechnology
基金
国家自然科学基金项目(30760009)
新疆大学校院联合资助项目(XY080107)资助
关键词
微生物
转化
重组菌株
麻黄碱
伪麻黄碱
microorganisms
transformation
recombinant strain
ephedrine
pseudoephedrine
