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降糖药发现过程回顾 被引量:1

Historical review fo Antidiabetic Drugs' discovery
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摘要 早在3500年前的古埃及时代,人们对与糖尿病相关的“多尿”已有记载。其后,人们对糖尿病的认识经历了多次演变,从单纯的症状记载到提出病变根本在肾脏,再认识至病变根源在胰腺;从认识到胰岛细胞,到胰岛素的分离提纯;从认识到磺胺药物具有降血糖作用,到二甲双胍类药物的问世,以及胰岛素注射方式的改进。回顾这一历史过程,有利于更好地认识及防治糖尿病。 Early in the ancient Egyptian period 3,500 years ago, people began to record the symptoms of diuresis related to Diabetes Mellitus. Thereafter, the cognition of Diabetes Mellitus in people evolved several times, that is: from simple symptom-recording to realizing that the essential pathogenesis is the kidney, and then recognizing that the root cause is the pancreas; from the cognition of islet cells to the separation and purification of insulin ; from recognizing that sulfonamides have a hyperglycemic action to the appearance of dimethyldiguanide and the improvement of the method of Insulin' s injection method. Reviewing this historical process can benefit a better realization and prevention and cure of Diabetes Mellitus.
作者 叶爱娇
出处 《中华医史杂志》 CAS 2009年第4期229-231,共3页 Chinese Journal of Medical History
关键词 糖尿病 DM 胰岛素 二甲双胍 Diabetes Mellitus DM Insulin Dimethyldiguanide
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共引文献64

同被引文献36

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