摘要
目的:探索磁共振靶向纳米造影剂在早期肺癌诊断方面的应用。方法:采用1.5TMR对直径为2～4mm的鼠肺癌模型做三种不同靶点纳米造影剂成像效果研究。结果:①靶点为血管内皮细胞生长因子受体(VEGFR)-1的纳米造影剂Pal-F56-Lip-Gd可以使肿瘤信号于15min迅速升高88%,1h为90%,2h为25%,3h为10%;②靶点为整合素αvβ3的Pal-RGD10-Lip-Gd可以使肿瘤信号于15min升高100%,1h达到160%,2h为120%,3h为70%;③靶点为VEGFR-2的Pal-K237-Lip-Gd可以使肿瘤信号于15min迅速升高91%,1h达到142%,2h为111%,3h为30%。结论:磁共振靶向纳米造影剂在肺癌早期诊断中具有潜在的应用前景,可以特异性地发现微小肿瘤结节。
Purpose： To study the value of lung neoplasm targeted nanotechnology MR contrast medium on early lung cancer. Methods： Three kinds of targeted MR contrast were used to image human lung adenocarcinoma implanted in nude mice with 1.5T MR, all the nodes were ranged from 2 to 4mm in size. Results： With palmitic acid - F56 - liposome Gd - DTPA - BMA（Pal - F56 - Lip - Gd） which targeted vascular endothelial growth factor receotor（VEGFR） - 1 , the signal of tumor was enhanced 88% in fifteen minutes,90% in one hour,25% in two hours and 10% in three hours. With Pal - RGD10- Lip - Gd which targted αvβ3, the signal of tumor was enhanced 100% in fifteen minutes, 160% in one hour, 120% in two hours and 70% in three hours. With Pal - K237 - Lip - Gd which targeted VEGFR - 2, the signal of tumor was enhanced 91% in fifteen minutes, 142% in one hour, 111% in two hours and 30% in three hours. Conclusion： Lung neoplasm targeted nanotechnology MR contrast can be used to diagnosis small tumors.
出处
《中国医学计算机成像杂志》
CSCD
北大核心
2009年第4期377-379,共3页
Chinese Computed Medical Imaging
基金
上海市纳米专项基金资助项目(编号0752nm018)~~
关键词
磁共振
靶向
纳米
造影剂
肺癌
Magnetic resonance imaging
Target
Nanotechnology
Contrast
Lung cancer
