摘要
目的探讨侵袭性肺曲霉病(IPA)的临床特点和诊断方法。方法回顾性分析我院2001年1月—2008年1月收治的21例IPA的基础疾病、临床症状和体征、影像学特征、治疗和预后情况。结果21例IPA患者确诊2例,拟诊19例。所有患者均有基础疾病,其中肝病为最多见的基础病(共12例,占57%)。社区感染7例,医院感染14例。主要症状为发热、咳嗽、咯血、胸痛及呼吸困难。14例行胸部CT检查,其中4例见"晕轮征",5例见"空气新月征"。接受治疗的15例患者中,治愈7例(46.7%),好转3例,治疗有效率66.7%。结论IPA病死率高,临床表现缺乏特异性,早期诊断和尽早应用抗曲霉药可降低病死率。
Objective To discuss the clinical features and diagnosis of invasive pulmonary aspergillosis （IPA）. Methods We reviewed the underlying diseases, symptoms, signs, radiology manifestations, treatment and prognosis of 21 IPA patients admitted to our hospital in the past 7 years from January 2001 to January 2008. Results Of the 21 patients, IPA was proven in 2 patients, and probable in 19 patients. All patients had some underlying diseases. Liver disease was the most common one （57 %）. Clinical manifestations included fever, cough, hemoptysis, chest pain and dyspnea. The IPA was nosocomial in 14 patients. Fourteen patients had chest CT scan. The findings showed ＂halo sign＂ in 4 patients and ＂air crescent sign＂ in 5 patients. Of the 15 patients receiving treatment, 7 （46.7%） were cured, 3 improved. The efficacy rate was 66.7%. Conclusions The clinical manifestation of IPA was non-specific. Therefore, early diagnosis and treatment are critical for reducing the mortality of IPA.
出处
《中国感染与化疗杂志》
CAS
2009年第2期137-139,共3页
Chinese Journal of Infection and Chemotherapy
关键词
侵袭性
肺曲霉病
诊断
invasion
lung aspergillosis
diagnosis
