摘要
目的:观察叶下珠治疗慢性乙型肝炎抗病毒疗效。方法:比较140例叶下珠治疗组和52例阿德福韦酯对照组患者抗病毒治疗慢性乙肝疗效。结果:叶下珠组和阿德福韦酯组在治疗的头3个月病毒应答率分别为54.3%、94.2%,差异有统计学意义(P<0.05)。随后,对叶下珠初期抗病毒有效病例组和阿德福韦酯组继续治疗2年,HBVDNA阴转率分别为88.2%、57.7%,差异有统计学意义(P<0.05)。HBeAg阳性阴转率分别为52.5%、43.2%,差异无统计学意义(P>0.05)。停药后12、24、36、48周叶下珠组病毒复发率分别为10.4%、10.6%、13.4%、12%,而对照组分别为为36.7%、46.7%、46.7%、48.3%,差异有统计学意义(P<0.05)。结论:叶下珠对慢性乙肝患者抗病毒治疗有效,叶下珠治疗有效的患者,HBeAg阳性阴转率、HBV DNA阴转率高,停药后病毒反弹率、复发率低,远期疗效好。
Objective： To investigate the therapeutical effect of phyllanthus pill on treating chronic hepatitis B. Methods： One hundred and forty cases of phyllanthus pill treatment group and 52 cases of adefovir control group patients with chronic hepatitis B were compared. Results： The early virus response rate of phyllanthus group and adefovir group was respectively 54. 3%, 94. 2%, P 〈0. 05. While patients with early virological response, HBV DNA negative conversion rate was respectively 88.2% and 57.7% , there differences were of statistical significance （ P 〈 0. 05 ） . HBeAg positive to negative rate was respectively 52. 5%, 43. 2%, there was no significant difference between them （P 〉0. 05） . After discontinuation of treatment 12 weeks, 24 weeks, 36 weeks and 48 weeks, the virus recurrence rate of phyllanthus pill group were 10. 4% , 10. 6% , 13.4% , 12% , while the control group was 6. 7%, 46. 7%, 46. 7%, 48.3% , there differences were of statistical significance （ P 〈 0. 05 ） ; Conclusion： Phyllanthus is effective to chronic hepatitis B, HBeAg-pesitive conversion rate and HBV DNA negative conversion rate are high. the important is that virus recurrence rate is low and have good long-term effleaey after withdrawal.
出处
《中西医结合肝病杂志》
CAS
2009年第4期195-197,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
