摘要
目的:检测血清间接胆红素(IBIL)及尿酸(UA)在单纯阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)及OSAHS合并冠心病(CHD)患者中的变化,探讨OSAHS的病理生理变化及OSAHS合并冠心病的发病机制。方法:将研究对象分为正常对照组20例、OS-AHS患者组31例、OSAHS合并冠心病患者组19例,检测和比较3组患者血清IBIL及UA水平。结果:OSAHS及OSAHS合并冠心病与正常对照组比较,血清IBIL降低,UA升高,差异均有统计学意义。结论:OSAHS患者存在胆红素及尿酸代谢异常,并可能参与OSAHS合并冠心病的发生。
Objective：To investigat the serum indirect bilirubin （IBIL） and ucid acid （UA） levels in patients with obstructive sleep apnea - hypopnea syndrome（OSAHS）without compilcations and in those with obsturctive sleep apnea - hypopnea syndrome associated coronary heart disease（OSAHS ＋ CHD）. To explore the change of pathophysiology in patients with OSAHS and the pathogenesis and predictor of OSAHS ＋ CHD. Methods ： All observed subjects were divided into 3 groups ： control subjects, OSAHS patients, OSAHS ＋ CHD patients. Serum IBIL and UA concentrations were measured and were compared among 3 groups. Results ： The serum IBIL levels in OSAHS and OSAHS ＋ CHD patients were apparently lower than those in control subjects（ P 〈 0.01）. The serum UA levels in OSAHS and OSAHS ＋ CHD patients were significantly higher than those in control subjects（ P 〈 0.01 ）. Conclusion ：There were abnormal metabolism of bilirubin and UA in patients with OSAHS, and the changes in the patients with OSAHS ＋ CHD were more singnificant.
出处
《长治医学院学报》
2009年第4期270-272,共3页
Journal of Changzhi Medical College
关键词
阻塞性睡眠呼吸暂停低通气综合征
冠心病
间接胆红素
尿酸
Obstructive sleep apnea - hypopnea syndrome
Coronary heart disease
Indirect bilirubin
Ucid acid
