摘要
探讨吸烟与宫内铅暴露及新生儿神经行为的关系。方法选择我院1992～1997年8～10月间足月新生儿396例，以脐血铅含量作为新生儿宫内铅暴露的指标，新生儿神经行为评分作为效应指标，评价孕妇吸烟与新生儿神经行为的关系。结果孕期被动吸烟和主动吸烟可使脐血铅水平明显升高，脐血铅含量平均值达0．52和0．61μmol／L，高于安全界限（0．48μmol／L）的新生儿分别占69％和79％。当济血钳含量高于0．48μmol／L时，对神经行为发育有显著影响，特别对行为能力中的非生物听定向反应、生物性视和听定向反应影响更明显。结论孕期被动和主动吸烟可提高济血铅水平，并进一步影响新生儿神经行为发育，特别是视和听功能。
Objective To research the relationship between smoking andintrautreine lead exposure and neonatal neutobehavioraldevelopmentMethods Umblical blood lead level, as an indicator forintrautreine lead exposure,and neurobehavioral score,as an effectindicator,were determined in 396 neonates in our hospital from 1992 to1997 Agust-October to explore the relationship between smokingin pregnancy and neonatal neurobehavioral development.Result Umbilical blood lead levels were increased obviously bypassive and initiative smoking during pregnancy. The mean of leadlevels were 0. 52μmol/L and 0. 61μmol/L repectively.meantime thenewborn exceeding the safety limits (0. 48μmol/L) were 69% and79% separately. It was also found that the neonatal neurobehavioraldevelopment was influenced obviously by the blood lead levelexceeding 0. 48μmol/L there were also significant differences innonbiologically auditoty and biological visual and auditory orientationreaction.Concludion During pregnancy by passive and initiativesmoking umbilical blood lead level can be enhanced, and smoking cancause adverse effects on neonatal neurobehavioraldevelopment,especially on their visual auditory function.
出处
《实用儿科临床杂志》
CAS
CSCD
1998年第4期221-222,共2页
Journal of Applied Clinical Pediatrics
基金
河南省自然科学基金!974020500
关键词
神经行为发育
新生儿
吸烟
脐血
铅
smoking
lead
new born
neurobehavioral development
