摘要
【目的】研究氟比洛芬酯和吗啡在开胸手术前使用是否有超前镇痛的效果，并对比其副作用。【方法】ASAⅠ～Ⅱ级肺和食管癌手术60例随机分为对照组、氟比洛芬酯组、吗啡组，每组20例。切皮前10min氟比洛芬酯组静注氟比洛芬酯100mg，吗啡组硬膜外腔注入吗啡3mg，对照组切皮前不做处理，观察各组术后30min、1h、4h、12h的VAS评分和24h内的副作用。【结果】氟比洛芬酯组术后30min和1hVAS评分明显低于对照组，但4h和12h和对照组无差别；吗啡组在4个时间点vAS评分均明显低于对照组和氟比洛芬酯组；副作用氟比洛芬酯组和对照组无差别，均明显低于吗啡组。【结论】切皮前氟比洛芬酯静脉注射和吗啡硬膜外腔注入均能产生超前镇痛的作用，吗啡的镇痛效果和时间均优于氟比洛芬酯，但副作用明显增多。
[Objective]To investigate the effect of preemptive analgesia of flurbiprofen axetil and morphine in the pre-operation of ＇thoracic surgery and to compare their side reactions. [Methods]Thirty ASA Ⅰ～Ⅱ patients undergoing lung cancer or esophageal cancer operations were randomly divided into control group（ n = 20）, flurbiprofen axetil group（ n =20） and morphine group（ n=20）. Patients in flurbiprofen axetil group received intravenous flurbiprofen axetil 100mg. Morphine 3mg was injected via epidural catheter into morphine group at 10min before skin incision. No treatment was performed in the control group at 10min before skin incision. The visual .analog scales （VAS） within 24h and the adverse effects were observed at 30min, 1, 4 aud 12h after operation. [Results] The VAS was significantly lower in flurbiprofen axetil group than that in control group at 30min and lh after operation. But there was no difference between two groups at 4 and 12h after operation. VAS was significantly lower in morphine group than that in control group and flurbiprofen axetil group at four time points after operation. There was no difference in adverse effects between control group and flurbiprofen axetil group. The side effects of these two groups were significantly less than those of morphine group. [Conclusion] Intravenous flurbiprofen axetil and epidural analgesia with morphine can yield the effect of preemptive analgesia. Epidural morphine has a better analgesic effect and time than intravenous flurbiprofen axetil. But morphine has more side effects than flurbiprofen axetil.
出处
《医学临床研究》
CAS
2009年第8期1398-1400,共3页
Journal of Clinical Research
