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原发性高血压患者血清瘦素与血管内皮舒张功能的关系探讨 被引量:1

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摘要 目的通过检测原发性高血压患者血清瘦素与血管内皮功能,探讨原发性高血压患者血清瘦素与血管内皮功能之间的可能关系。方法原发性高血压者33例和非高血压患者18例,分别测定血清瘦素,血糖和血脂;采用高分辨率彩超检测肱动脉血流介导的内皮依赖性和非内皮依赖性血管舒张功能。结果与对照组相比,原发性高血压患者血清瘦素水平高(3.553±0.107vs3.436±0.095ng/ml,P<0.01)。与对照组比较,原发性高血压患者肱动脉内径无明显差别(0.387±0.601vs0.354±0.607mm,P>0.05);肱动脉血流介导的内皮依赖性血管舒张功能(EDF)差异有统计学意义(15.58±4.701%vs19.38±6.452%,P<0.05);肱动脉血流介导的非内皮依赖性血管舒张功能(NEDF)差异无统计学意义(17.095±4.412%vs19.648±4.635%,P>0.05)。瘦素与血管舒张功能之间的Pearson相关分析,未发现有明显的相关关系。结论原发性高血压患者血清瘦素增高与肱动脉血流介导的内皮依赖性血管舒张功能减退可能无关。
出处 《福建医药杂志》 CAS 2009年第4期31-33,共3页 Fujian Medical Journal
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